P2X purinoreceptor
The P2X receptors, also ATP-gated P2X receptor cation channel family, is a protein family that consists of cation-permeable ligand-gated ion channels that open in response to the binding of extracellular adenosine 5'-triphosphate (ATP). They belong to a larger family of receptors known as the ENaC/P2X superfamily. ENaC and P2X receptors have similar 3-D structures and are homologous. P2X receptors are present in a diverse array of organisms including humans, mouse, rat, rabbit, chicken, zebrafish, bullfrog, fluke, and amoeba.
| ATP P2X receptor | |||||||||
|---|---|---|---|---|---|---|---|---|---|
Figure 1. Schematic representation showing the membrane topology of a typical P2X receptor subunit. First and second transmembrane domains are labeled TM1 and TM2. | |||||||||
| Identifiers | |||||||||
| Symbol | P2X_receptor | ||||||||
| Pfam | PF00864 | ||||||||
| InterPro | IPR001429 | ||||||||
| PROSITE | PDOC00932 | ||||||||
| TCDB | 1.A.7 | ||||||||
| OPM superfamily | 181 | ||||||||
| OPM protein | 3h9v | ||||||||
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