P2RY14

P2RY14
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2B6V
Identifiers
Aliases	P2RY14, BPR105, GPR105, P2Y14, purinergic receptor P2Y14
External IDs	OMIM: 610116 MGI: 2155705 HomoloGene: 15769 GeneCards: P2RY14
Gene location (Human)
Chr.	Chromosome 3 (human)
End	151,278,542 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	59,061,039 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; synovial joint; ; Achilles tendon; ; endometrium; ; gastric mucosa; ; visceral pleura; ; right lung; ; cecum; ; rectum; ; appendix;
	Top expressed in
	cervix; ; sciatic nerve; ; spleen; ; adrenal gland; ; external carotid artery; ; left lung lobe; ; Paneth cell; ; carotid body; ; iris; ; ileum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	G protein-coupled purinergic nucleotide receptor activity; G protein-coupled UDP receptor activity; G protein-coupled receptor activity; signal transducer activity;
Cellular component	integral component of membrane; plasma membrane; integral component of plasma membrane; membrane;
Biological process	signal transduction; G protein-coupled purinergic nucleotide receptor signaling pathway; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	9934
	140795
	ENSG00000174944
	ENSMUSG00000036381
	Q15391
	Q9ESG6
	NM_001081455; NM_014879
NM_001008497; NM_001287119; NM_001287120; NM_001287121; NM_001287122;
	NM_001287123; NM_001287124; NM_133200
	NP_001074924; NP_055694
NP_001008497; NP_001274048; NP_001274049; NP_001274050; NP_001274051;
	NP_001274052; NP_001274053; NP_573463
	Wikidata
View/Edit Human	View/Edit Mouse

P2Y purinoceptor 14 is a protein that in humans is encoded by the P2RY14 gene.

The product of this gene, P2Y₁₄ belongs to the family of G-protein coupled receptors, which contains several receptor subtypes with different pharmacological selectivity for various adenosine and uridine nucleotides. This receptor is a P2Y purinergic receptor for UDP-glucose and other UDP-sugars coupled to G-proteins. It has been implicated in extending the known immune system functions of P2Y receptors by participating in the regulation of the stem cell compartment, and it may also play a role in neuroimmune function. Two transcript variants encoding the same protein have been identified for this gene.

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