p21

CDKN1A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1AXC, 2ZVV, 2ZVW, 4RJF, 5E0U
Identifiers
Aliases	CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1, cyclin-dependent kinase inhibitor 1A, cyclin dependent kinase inhibitor 1A
External IDs	OMIM: 116899 MGI: 104556 HomoloGene: 333 GeneCards: CDKN1A
Gene location (Human)
Chr.	Chromosome 6 (human)
End	36,687,339 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	29,319,701 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; gastric mucosa; ; vena cava; ; left uterine tube; ; ascending aorta; ; saphenous vein; ; popliteal artery; ; mucosa of urinary bladder; ; skin of abdomen; ; gallbladder;
	Top expressed in
	calvaria; ; molar; ; pyloric antrum; ; lip; ; esophagus; ; hair follicle; ; epithelium of stomach; ; condyle; ; sciatic nerve; ; left colon;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	metal ion binding; protein binding; cyclin-dependent protein serine/threonine kinase inhibitor activity; ubiquitin protein ligase binding; cyclin binding; cyclin-dependent protein kinase activating kinase activity; cyclin-dependent protein serine/threonine kinase activity; protein kinase inhibitor activity; protein kinase binding; protein-containing complex binding;
Cellular component	cytoplasm; cytosol; cyclin-dependent protein kinase holoenzyme complex; PCNA-p21 complex; perinuclear region of cytoplasm; nucleus; nucleoplasm; nucleolus; nuclear body; protein-containing complex;
Biological process	cellular response to extracellular stimulus; signal transduction by p53 class mediator; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; cellular response to heat; regulation of cyclin-dependent protein serine/threonine kinase activity; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; positive regulation of cell death; response to organic cyclic compound; negative regulation of cyclin-dependent protein serine/threonine kinase activity; stress-induced premature senescence; positive regulation of fibroblast proliferation; replicative senescence; response to hyperoxia; response to corticosterone; cellular response to amino acid starvation; positive regulation of programmed cell death; negative regulation of apoptotic process; response to glucocorticoid; response to arsenic-containing substance; regulation of DNA biosynthetic process; response to organic substance; negative regulation of gene expression; cellular response to DNA damage stimulus; negative regulation of G1/S transition of mitotic cell cycle; regulation of cell cycle; intrinsic apoptotic signaling pathway; cellular senescence; positive regulation of reactive oxygen species metabolic process; cellular response to UV-B; G2/M transition of mitotic cell cycle; positive regulation of B cell proliferation; negative regulation of cell growth; response to organonitrogen compound; animal organ regeneration; regulation of mitotic cell cycle; intestinal epithelial cell maturation; cellular response to ionizing radiation; cell cycle; Ras protein signal transduction; negative regulation of phosphorylation; response to toxic substance; response to UV; response to X-ray; negative regulation of cell population proliferation; protein stabilization; positive regulation of cyclin-dependent protein kinase activity; regulation of transcription by RNA polymerase II; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; positive regulation of protein kinase activity; cellular response to gamma radiation; negative regulation of cyclin-dependent protein kinase activity; transcription initiation from RNA polymerase II promoter; G1/S transition of mitotic cell cycle; cytokine-mediated signaling pathway; negative regulation of vascular associated smooth muscle cell proliferation;
	Sources:Amigo / QuickGO
Orthologs
	1026
	12575
	ENSG00000124762
	ENSMUSG00000023067
	P38936
	P39689
	NM_078467; NM_000389; NM_001220777; NM_001220778; NM_001291549
	NM_001111099; NM_007669
NP_000380; NP_001207706; NP_001207707; NP_001278478; NP_510867;
	NP_001361438; NP_001361439; NP_001361440; NP_001361441; NP_001361442
	NP_001104569; NP_031695
	Wikidata
View/Edit Human	View/Edit Mouse

p21^Cip1 (alternatively p21^Waf1), also known as cyclin-dependent kinase inhibitor 1 or CDK-interacting protein 1, is a cyclin-dependent kinase inhibitor (CKI) that is capable of inhibiting all cyclin/CDK complexes, though is primarily associated with inhibition of CDK2. p21 represents a major target of p53 activity and thus is associated with linking DNA damage to cell cycle arrest. This protein is encoded by the CDKN1A gene located on chromosome 6 (6p21.2) in humans.

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