P110δ

PIK3CD
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	5DXU
Identifiers
Aliases	PIK3CD, APDS, IMD14, P110DELTA, PI3K, p110D, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta, IMD14B, ROCHIS, IMD14A
External IDs	OMIM: 602839 MGI: 1098211 HomoloGene: 3686 GeneCards: PIK3CD
Gene location (Human)
Chr.	Chromosome 1 (human)
End	9,729,114 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	149,787,028 bp
RNA expression pattern
	Top expressed in
	blood; ; lymph node; ; spongy bone; ; spleen; ; monocyte; ; appendix; ; bone marrow cells; ; periodontal fiber; ; frontal pole; ; thymus;
	Top expressed in
	secondary oocyte; ; spleen; ; blood; ; thymus; ; spermatid; ; seminiferous tubule; ; yolk sac; ; subcutaneous adipose tissue; ; spermatocyte; ; superior frontal gyrus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; 1-phosphatidylinositol-4-phosphate 3-kinase activity; protein binding; ATP binding; kinase activity; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; 1-phosphatidylinositol-3-kinase activity; phosphatidylinositol 3-kinase activity; phosphatidylinositol-3,4-bisphosphate 5-kinase activity;
Cellular component	phosphatidylinositol 3-kinase complex; cytosol; plasma membrane; mast cell granule; cytoplasm; membrane; intracellular anatomical structure;
Biological process	B cell receptor signaling pathway; cell differentiation; adaptive immune response; respiratory burst involved in defense response; B cell chemotaxis; immune system process; positive regulation of cell migration; T cell chemotaxis; cytokine production; natural killer cell activation; mast cell chemotaxis; neutrophil chemotaxis; chemotaxis; T cell differentiation; phosphatidylinositol phosphate biosynthetic process; positive regulation of gene expression; natural killer cell chemotaxis; mast cell differentiation; mast cell degranulation; innate immune response; inflammatory response; neutrophil extravasation; T cell receptor signaling pathway; T cell activation; signal transduction; natural killer cell differentiation; B cell activation; phosphatidylinositol-3-phosphate biosynthetic process; axon guidance; phosphorylation; protein phosphorylation; platelet activation; positive regulation of neutrophil apoptotic process; phosphatidylinositol-mediated signaling; positive regulation of protein kinase B signaling; phosphatidylinositol 3-kinase signaling; cytokine-mediated signaling pathway; negative regulation of gene expression; cell migration; positive regulation of phosphatidylinositol 3-kinase signaling; phosphatidylinositol biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	5293
	18707
	ENSG00000171608
	ENSMUSG00000039936
	O00329
	O35904
	NM_005026; NM_001350234; NM_001350235
NM_001029837; NM_001164049; NM_001164050; NM_001164051; NM_001164052;
	NM_008840
	NP_005017; NP_001337163; NP_001337164; NP_005017.3
NP_001025008; NP_001157521; NP_001157522; NP_001157523; NP_001157524;
	NP_032866
	Wikidata
View/Edit Human	View/Edit Mouse

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform also known as phosphoinositide 3-kinase (PI3K) delta isoform or p110δ is an enzyme that in humans is encoded by the PIK3CD gene.

p110δ regulates immune function. In contrast to the other class IA PI3Ks p110α and p110β, p110δ is principally expressed in leukocytes (white blood cells). Genetic and pharmacological inactivation of p110δ has revealed that this enzyme is important for the function of T cells, B cell, mast cells and neutrophils. Hence, p110δ is a promising target for drugs that aim to prevent or treat inflammation, autoimmunity and transplant rejection.

Phosphoinositide 3-kinases (PI3Ks) phosphorylate the 3-prime OH position of the inositol ring of inositol lipids. The class I PI3Ks display a broad phosphoinositide lipid substrate specificity and include p110α, p110β and p110γ. p110α and p110β interact with SH2/SH3-domain-containing p85 adaptor proteins and with GTP-bound Ras.

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