Orotic acid

Orotic acid
Clinical data
Other names	uracil-6-carboxylic acid
AHFS/Drugs.com	International Drug Names
ATC code	none;
Identifiers
	IUPAC name 1,2,3,6-Tetrahydro-2,6-dioxo-4-pyrimidinecarboxylic acid;
CAS Number	65-86-1 ;
PubChem CID	967;
IUPHAR/BPS	4690;
DrugBank	DB02262 ;
ChemSpider	942 ;
UNII	61H4T033E5;
KEGG	C00295 ;
CompTox Dashboard (EPA)	DTXSID0025814 ;
ECHA InfoCard	100.000.563
Chemical and physical data
Formula	C5H4N2O4
Molar mass	156.097 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(O)\C1=C\C(=O)NC(=O)N1;
	InChI InChI=1S/C5H4N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h1H,(H,9,10)(H2,6,7,8,11) ; Key:PXQPEWDEAKTCGB-UHFFFAOYSA-N ;
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Orotic acid (/ɔːˈrɒtɪk/) is a pyrimidinedione and a carboxylic acid. Historically, it was believed to be part of the vitamin B complex and was called vitamin B₁₃, but it is now known that it is not a vitamin.

The compound is synthesized in the body via a mitochondrial enzyme, dihydroorotate dehydrogenase or a cytoplasmic enzyme of pyrimidine synthesis pathway. It is sometimes used as a mineral carrier in some dietary supplements (to increase their bioavailability), most commonly for lithium orotate.

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