OXCT1

OXCT1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3DLX
Identifiers
Aliases	OXCT1, OXCT, SCOT, 3-oxoacid CoA-transferase 1
External IDs	OMIM: 601424 MGI: 1914291 HomoloGene: 377 GeneCards: OXCT1
Gene location (Human)
Chr.	Chromosome 5 (human)
End	41,870,519 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	4,184,826 bp
RNA expression pattern
	Top expressed in
	right ventricle; ; endothelial cell; ; middle temporal gyrus; ; Achilles tendon; ; orbitofrontal cortex; ; Brodmann area 46; ; superior frontal gyrus; ; postcentral gyrus; ; tibia; ; prefrontal cortex;
	Top expressed in
	kidney; ; epithelium of stomach; ; myocardium of ventricle; ; medial dorsal nucleus; ; lateral geniculate nucleus; ; digastric muscle; ; hair follicle; ; ciliary body; ; intercostal muscle; ; right ventricle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; protein homodimerization activity; 3-oxoacid CoA-transferase activity; CoA-transferase activity;
Cellular component	mitochondrial matrix; mitochondrion; nucleoplasm;
Biological process	response to nutrient; response to activity; heart development; brain development; ketone body catabolic process; response to starvation; response to hormone; adipose tissue development; ketone catabolic process; positive regulation of insulin secretion involved in cellular response to glucose stimulus; metabolism; response to ethanol; cellular ketone body metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	5019
	67041
	ENSG00000083720
	ENSMUSG00000022186
	P55809
	Q9D0K2
	NM_000436
	NM_024188
NP_000427; NP_001351228; NP_001351229; NP_001351230; NP_001351231;
	NP_001351232
	NP_077150
	Wikidata
View/Edit Human	View/Edit Mouse

3-oxoacid CoA-transferase 1 (OXCT1) is an enzyme that in humans is encoded by the OXCT1 gene. It is also known as succinyl-CoA-3-oxaloacid CoA transferase (SCOT). Mutations in the OXCT1 gene are associated with succinyl-CoA:3-oxoacid CoA transferase deficiency. This gene encodes a member of the 3-oxoacid CoA-transferase gene family. The encoded protein is a homodimeric mitochondrial matrix enzyme that plays a central role in extrahepatic ketone body catabolism by catalyzing the reversible transfer of coenzyme A (CoA) from succinyl-CoA to acetoacetate.

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