ORAI1

ORAI1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2MAK, 4EHQ
Identifiers
Aliases	ORAI1, CRACM1, IMD9, ORAT1, TAM2, TMEM142A, ORAI calcium release-activated calcium modulator 1
External IDs	OMIM: 610277 MGI: 1925542 HomoloGene: 13117 GeneCards: ORAI1
Gene location (Human)
Chr.	Chromosome 12 (human)
End	121,642,677 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	123,168,519 bp
RNA expression pattern
	Top expressed in
	skin of abdomen; ; gastrocnemius muscle; ; monocyte; ; blood; ; spleen; ; biceps brachii; ; upper lobe of left lung; ; appendix; ; minor salivary gland; ; right lung;
	Top expressed in
	triceps brachii muscle; ; temporal muscle; ; sternocleidomastoid muscle; ; extraocular muscle; ; digastric muscle; ; ankle; ; thoracic diaphragm; ; vastus lateralis muscle; ; internal carotid artery; ; secondary oocyte;
	More reference expression data
	n/a
Gene ontology
Molecular function	store-operated calcium channel activity; calcium channel activity; calmodulin binding; protein binding; identical protein binding;
Cellular component	integral component of membrane; membrane; integral component of plasma membrane; plasma membrane;
Biological process	regulation of calcium ion transport; adaptive immune response; immune system process; ion transport; calcium ion transmembrane transport; calcium ion transport; positive regulation of calcium ion transport; store-operated calcium entry; transport;
	Sources:Amigo / QuickGO
Orthologs
	84876
	109305
	ENSG00000276045
	ENSMUSG00000049686
	Q96D31
	Q8BWG9
	NM_032790
	NM_175423
	NP_116179
	NP_780632
	Wikidata
View/Edit Human	View/Edit Mouse

Calcium release-activated calcium channel protein 1 is a calcium selective ion channel that in humans is encoded by the ORAI1 gene. Orai channels play an important role in the activation of T-lymphocytes. The loss of function mutation of Orai1 causes severe combined immunodeficiency (SCID) in humans The mammalian orai family has two additional homologs, Orai2 and Orai3. Orai proteins share no homology with any other ion channel family of any other known proteins. They have 4 transmembrane domains and form hexamers.

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