Solute carrier organic anion transporter family member 1B3

SLCO1B3
Identifiers
Aliases	SLCO1B3, HBLRR, LST-2, LST-3TM13, LST3, OATP-8, OATP1B3, OATP8, SLC21A8, solute carrier organic anion transporter family member 1B3
External IDs	OMIM: 605495 MGI: 1351899 HomoloGene: 75119 GeneCards: SLCO1B3
Gene location (Human)
Chr.	Chromosome 12 (human)
End	20,916,911 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	141,632,372 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; tibial nerve; ; canal of the cervix; ; gallbladder; ; sural nerve; ; minor salivary gland; ; visceral pleura; ; rectum; ; testicle; ; smooth muscle tissue;
	Top expressed in
	left lobe of liver; ; sexually immature organism; ; proximal tubule; ; jejunum; ; thoracic diaphragm; ; pancreas; ; placenta; ; islet of Langerhans; ; spleen; ; esophagus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transporter activity; organic anion transmembrane transporter activity; bile acid transmembrane transporter activity; sodium-independent organic anion transmembrane transporter activity;
Cellular component	integral component of membrane; basolateral plasma membrane; integral component of plasma membrane; membrane; plasma membrane;
Biological process	ion transport; bile acid and bile salt transport; organic anion transport; sodium-independent organic anion transport; transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	28234
	28253
	ENSG00000111700
	ENSMUSG00000030236
	Q9NPD5
	Q9JJL3
	NM_019844; NM_001349920
	NM_020495; NM_178235
	NP_062818; NP_001336849
	NP_065241
	Wikidata
View/Edit Human	View/Edit Mouse

Solute carrier organic anion transporter family member 1B3 (SLCO1B3) also known as organic anion-transporting polypeptide 1B3 (OATP1B3) is a protein that in humans is encoded by the SLCO1B3 gene.

OATP1B3 is a 12-transmembrane domain influx transporter. Normally expressed in the liver, the transporter functions to uptake large, non-polar drugs and hormones from the portal vein.

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