Nuclear receptor 4A3

NR4A3
Identifiers
Aliases	NR4A3, CHN, CSMF, MINOR, NOR1, TEC, nuclear receptor subfamily 4 group A member 3
External IDs	OMIM: 600542 MGI: 1352457 HomoloGene: 5074 GeneCards: NR4A3
Gene location (Human)
Chr.	Chromosome 9 (human)
End	99,866,891 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	48,086,447 bp
RNA expression pattern
	Top expressed in
	mucosa of urinary bladder; ; gastric mucosa; ; vena cava; ; gallbladder; ; right ventricle; ; popliteal artery; ; left uterine tube; ; parietal pleura; ; kidney tubule; ; gastrocnemius muscle;
	Top expressed in
	Region I of hippocampus proper; ; seminal vesicula; ; hippocampus proper; ; adrenal gland; ; dentate gyrus; ; amygdala; ; subiculum; ; extraocular muscle; ; prefrontal cortex; ; tibialis anterior muscle;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; sequence-specific DNA binding; protein homodimerization activity; DNA-binding transcription factor activity; zinc ion binding; DNA-binding transcription activator activity, RNA polymerase II-specific; metal ion binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; steroid hormone receptor activity; nuclear receptor activity; core promoter sequence-specific DNA binding; protein binding; histone acetyltransferase binding; glucocorticoid receptor binding; transcription coactivator binding; protein kinase binding; DNA-binding transcription factor activity, RNA polymerase II-specific; cAMP response element binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding;
Cellular component	transcription regulator complex; mast cell granule; nucleoplasm; nucleus;
Biological process	negative regulation of neuron apoptotic process; cellular response to catecholamine stimulus; semicircular canal morphogenesis; regulation of transcription, DNA-templated; neuromuscular process controlling balance; positive regulation of epithelial cell proliferation; common myeloid progenitor cell proliferation; pyruvate oxidation; negative regulation of oxidative stress-induced neuron death; mesoderm formation; response to peptide hormone; negative regulation of apoptotic process; positive regulation of leukocyte apoptotic process; negative regulation of transcription by RNA polymerase II; regulation of smooth muscle cell proliferation; cellular response to leptin stimulus; transcription, DNA-templated; positive regulation of cardiac muscle hypertrophy; axon guidance; positive regulation of transcription, DNA-templated; adult behavior; positive regulation of cell cycle; negative regulation of hydrogen peroxide-induced neuron death; gastrulation; positive regulation of mast cell activation by Fc-epsilon receptor signaling pathway; animal organ regeneration; inner ear morphogenesis; positive regulation of mast cell cytokine production; cellular respiration; vestibular reflex; energy homeostasis; cellular response to corticotropin-releasing hormone stimulus; mast cell degranulation; transcription initiation from RNA polymerase II promoter; positive regulation of feeding behavior; positive regulation of glucose transmembrane transport; hippocampus development; positive regulation of monocyte aggregation; fat cell differentiation; response to hydrogen peroxide; regulation of type B pancreatic cell proliferation; positive regulation of transcription by RNA polymerase II; steroid hormone mediated signaling pathway; positive regulation of smooth muscle cell proliferation; positive regulation of fatty acid oxidation; intracellular receptor signaling pathway; regulation of megakaryocyte differentiation; platelet-derived growth factor receptor signaling pathway; positive regulation of vascular associated smooth muscle cell proliferation; positive regulation of vascular associated smooth muscle cell migration;
	Sources:Amigo / QuickGO
Orthologs
	8013
	18124
	ENSG00000119508
	ENSMUSG00000028341
	Q92570
	Q9QZB6
	NM_006981; NM_173198; NM_173199; NM_173200
	NM_015743; NM_001307989
	NP_008912; NP_775291; NP_775292
	NP_001294918; NP_056558
	Wikidata
View/Edit Human	View/Edit Mouse

The nuclear receptor 4A3 (NR4A3) (nuclear receptor subfamily 4, group A, member 3) also known as neuron-derived orphan receptor 1 (NOR1) is a protein that in humans is encoded by the NR4A3 gene. NR4A3 is a member of the nuclear receptor family of intracellular transcription factors.

NR4A3 plays a central regulatory role in cell proliferation, differentiation, mitochondrial respiration, metabolism and apoptosis

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