Norrin

NDP
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4MY2, 5BPU, 5BQ8, 5BQB, 5BQC, 5BQE, 5CL1
Identifiers
Aliases	NDP, EVR2, FEVR, ND, Norrie disease (pseudoglioma), norrin cystine knot growth factor, norrin cystine knot growth factor NDP
External IDs	OMIM: 300658 MGI: 102570 HomoloGene: 225 GeneCards: NDP
Gene location (Human)
Chr.	X chromosome (human)
End	43,973,395 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	16,778,013 bp
RNA expression pattern
	Top expressed in
	optic nerve; ; caudate nucleus; ; putamen; ; amygdala; ; nucleus accumbens; ; Brodmann area 9; ; internal globus pallidus; ; external globus pallidus; ; cerebellar hemisphere; ; prefrontal cortex;
	Top expressed in
	respiratory epithelium; ; olfactory epithelium; ; sciatic nerve; ; stria vascularis; ; entorhinal cortex; ; cerebellar cortex; ; superior frontal gyrus; ; Purkinje cell; ; cingulate gyrus; ; ganglion cell layer;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein homodimerization activity; frizzled binding; protein binding; growth factor activity; cytokine activity;
Cellular component	extracellular matrix; extracellular region; cell surface; extracellular space; collagen-containing extracellular matrix;
Biological process	extracellular matrix-cell signaling; response to stimulus; placenta development; cell-cell signaling; positive regulation of DNA-binding transcription factor activity; vacuole organization; Wnt signaling pathway; sensory perception of sound; nervous system development; positive regulation of transcription, DNA-templated; canonical Wnt signaling pathway; cell population proliferation; retina vasculature morphogenesis in camera-type eye; signal transduction; visual perception; regulation of signaling receptor activity; Norrin signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	4693
	17986
	ENSG00000124479
	ENSMUSG00000040138
	Q00604
	P48744
	NM_000266
	NM_010883
	NP_000257
	NP_035013
	Wikidata
View/Edit Human	View/Edit Mouse

Norrin, also known as Norrie disease protein or X-linked exudative vitreoretinopathy 2 protein (EVR2) is a protein that in humans is encoded by the NDP gene. Mutations in the NDP gene are associated with the Norrie disease.

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