Normethadone

Normethadone
Clinical data
Trade names	Cophylac
ATC code	R05DA06 (WHO) ;
Legal status
Legal status	AU: S9 (Prohibited substance); BR: Class A1 (Narcotic drugs); CA: Schedule I; DE: Anlage III (Special prescription form required); US: Schedule I;
Pharmacokinetic data
Bioavailability	100%
Metabolism	liver
Elimination half-life	14 days
Excretion	Urine
Identifiers
	IUPAC name 6-dimethylamino-4,4-diphenyl-hexan-3-one;
CAS Number	467-85-6 ; 847-84-7 (HCl);
PubChem CID	10090;
ChemSpider	9687 ;
UNII	KR2L2A68XL;
KEGG	D07384 ;
ChEMBL	ChEMBL346331 ;
CompTox Dashboard (EPA)	DTXSID6057748 ;
ECHA InfoCard	100.006.730
Chemical and physical data
Formula	C20H25NO
Molar mass	295.426 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(C(c1ccccc1)(c2ccccc2)CCN(C)C)CC;
	InChI InChI=1S/C20H25NO/c1-4-19(22)20(15-16-21(2)3,17-11-7-5-8-12-17)18-13-9-6-10-14-18/h5-14H,4,15-16H2,1-3H3 ; Key:WCJFBSYALHQBSK-UHFFFAOYSA-N ;
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Normethadone (INN, BAN; brand names Ticarda, Cophylac, Dacartil, Eucopon, Mepidon, Noramidone, Normedon, and others), also known as desmethylmethadone or phenyldimazone, is a synthetic opioid analgesic and antitussive agent. Normethadone is listed under the Single Convention on Narcotic Drugs 1961 and is a Schedule I Narcotic controlled substance in the United States, with a DEA ACSCN of 9635 and an annual manufacturing quota of 2 grams. It has an effective span of action for about 14 days, and is 12 to 20 times stronger than morphine. The salts in use are the hydrobromide (free base conversion ratio 0.785), hydrochloride (0.890), methyliodide (0.675), oxalate (0.766), picrate (0.563), and the 2,6-ditertbutylnapthalindisulphonate (0.480).

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