Nociceptin receptor

OPRL1
Available structures
PDB	Ortholog search: A0A0G2JQE4 PDBe A0A0G2JQE4 RCSB
List of PDB id codes
	4EA3, 5DHG, 5DHH
Identifiers
Aliases	OPRL1, KOR-3, NOCIR, OOR, ORL1, NOP, NOPr, opioid related nociceptin receptor 1, KOR3, OPRL, PNOCR
External IDs	OMIM: 602548 MGI: 97440 HomoloGene: 22609 GeneCards: OPRL1
Gene location (Human)
Chr.	Chromosome 20 (human)
End	64,100,643 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	181,362,778 bp
RNA expression pattern
	Top expressed in
	blood; ; superior frontal gyrus; ; Brodmann area 9; ; monocyte; ; nucleus accumbens; ; hypothalamus; ; prefrontal cortex; ; caudate nucleus; ; putamen; ; stromal cell of endometrium;
	Top expressed in
	ventromedial nucleus; ; dorsomedial hypothalamic nucleus; ; paraventricular nucleus of hypothalamus; ; arcuate nucleus; ; lateral hypothalamus; ; ventral tegmental area; ; mammillary body; ; dorsal tegmental nucleus; ; habenula; ; median eminence;
	More reference expression data
	n/a
Gene ontology
Molecular function	nociceptin receptor activity; neuropeptide binding; signal transducer activity; G protein-coupled opioid receptor activity; protein binding; G protein-coupled receptor activity; protein C-terminus binding; peptide binding;
Cellular component	integral component of membrane; membrane; plasma membrane; integral component of plasma membrane; neuron projection; cytoplasmic vesicle;
Biological process	response to estradiol; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; sensory perception; positive regulation of urine volume; eating behavior; regulation of sensory perception of pain; negative regulation of blood pressure; estrous cycle; regulation of locomotor rhythm; positive regulation of gastric acid secretion; positive regulation of sensory perception of pain; sensory perception of pain; negative regulation of voltage-gated calcium channel activity; neuropeptide signaling pathway; signal transduction; chemical synaptic transmission; G protein-coupled receptor signaling pathway; animal behaviour; negative regulation of cAMP-mediated signaling; negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway; G protein-coupled opioid receptor signaling pathway; positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway; conditioned place preference;
	Sources:Amigo / QuickGO
Orthologs
	4987
	18389
	ENSG00000277044; ENSG00000125510
	ENSMUSG00000027584
	P41146
	P35377
NM_000913; NM_001200019; NM_182647; NM_001318853; NM_001318854;
	NM_001318855
NM_001252565; NM_011012; NM_001318919; NM_001318920; NM_001318922;
	NM_001318923; NM_001318924; NM_001318925
NP_000904; NP_001186948; NP_001305782; NP_001305783; NP_001305784;
	NP_872588
NP_001239494; NP_001305848; NP_001305849; NP_001305851; NP_001305852;
	NP_001305853; NP_001305854; NP_035142
	Wikidata
View/Edit Human	View/Edit Mouse

The nociceptin opioid peptide receptor (NOP)_, also known as the nociceptin/orphanin FQ (N/OFQ) receptor or kappa-type 3 opioid receptor, is a protein that in humans is encoded by the OPRL1 (opioid receptor-like 1) gene. The nociceptin receptor is a member of the opioid subfamily of G protein-coupled receptors whose natural ligand is the 17 amino acid neuropeptide known as nociceptin (N/OFQ). This receptor is involved in the regulation of numerous brain activities, particularly instinctive and emotional behaviors. Antagonists targeting NOP are under investigation for their role as treatments for depression and Parkinson's disease, whereas NOP agonists have been shown to act as powerful, non-addictive painkillers in non-human primates.

Although NOP shares high sequence identity (~60%) with the ‘classical’ opioid receptors μ-OP (MOP), κ-OP (KOP), and δ-OP (DOP), it possesses little or no affinity for opioid peptides or morphine-like compounds. Likewise, classical opioid receptors possess little affinity towards NOP's endogenous ligand nociceptin, which is structurally related to dynorphin A.

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