Nitric oxide synthase 2 (inducible)

NOS2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1NSI, 2LL6, 2NSI, 3E7G, 3EJ8, 3HR4, 4CX7, 4NOS
Identifiers
Aliases	NOS2, HEP-NOS, INOS, NOS, NOS2A, Nitric oxide synthase 2
External IDs	OMIM: 163730 MGI: 97361 HomoloGene: 55473 GeneCards: NOS2
Gene location (Human)
Chr.	Chromosome 17 (human)
End	27,800,529 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	78,851,080 bp
RNA expression pattern
	Top expressed in
	rectum; ; appendix; ; prefrontal cortex; ; duodenum; ; Brodmann area 9; ; cingulate gyrus; ; upper lobe of left lung; ; right lung; ; ganglionic eminence; ; smooth muscle tissue;
	Top expressed in
	jejunum; ; placenta; ; thymus; ; entorhinal cortex; ; skeletal muscle tissue; ; esophagus; ; neural tube; ; adrenal gland; ; lens; ; stomach;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	FMN binding; protein homodimerization activity; flavin adenine dinucleotide binding; arginine binding; tetrahydrobiopterin binding; metal ion binding; calmodulin binding; protein binding; heme binding; oxidoreductase activity; signaling receptor binding; nitric-oxide synthase activity; NADPH-hemoprotein reductase activity; NADP binding;
Cellular component	cytoplasm; cytosol; cortical cytoskeleton; peroxisome; intracellular anatomical structure; perinuclear region of cytoplasm; nucleus; peroxisomal matrix; plasma membrane; vesicle membrane;
Biological process	positive regulation of guanylate cyclase activity; response to hypoxia; nitric oxide biosynthetic process; positive regulation of leukocyte mediated cytotoxicity; response to bacterium; negative regulation of protein catabolic process; regulation of insulin secretion; negative regulation of blood pressure; regulation of cytokine production involved in inflammatory response; positive regulation of killing of cells of other organism; negative regulation of gene expression; cell redox homeostasis; arginine catabolic process; prostaglandin secretion; response to lipopolysaccharide; innate immune response in mucosa; regulation of cell population proliferation; peptidyl-cysteine S-nitrosylation; defense response to bacterium; circadian rhythm; defense response to Gram-negative bacterium; nitric oxide mediated signal transduction; cellular response to interferon-gamma; regulation of cellular respiration; cellular response to lipopolysaccharide; superoxide metabolic process; cytokine-mediated signaling pathway; protein targeting to peroxisome; response to hormone;
	Sources:Amigo / QuickGO
Orthologs
	4843
	18126
	ENSG00000007171
	ENSMUSG00000020826
	P35228
	P29477
	NM_000625; NM_153292
	NM_010927; NM_001313921; NM_001313922
	NP_000616
	NP_001300850; NP_001300851; NP_035057
	Wikidata
View/Edit Human	View/Edit Mouse

Nitric oxide synthase, inducible is an enzyme which is encoded by the NOS2 gene in humans and mice.

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