Neuroserpin

SERPINI1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3F02, 3F5N, 3FGQ
Identifiers
Aliases	SERPINI1, PI12, neuroserpin, serpin family I member 1, HNS-S2, HNS-S1
External IDs	OMIM: 602445 MGI: 1194506 HomoloGene: 21045 GeneCards: SERPINI1
Gene location (Human)
Chr.	Chromosome 3 (human)
End	167,825,569 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	75,550,802 bp
RNA expression pattern
	Top expressed in
	frontal pole; ; orbitofrontal cortex; ; Brodmann area 10; ; middle temporal gyrus; ; superior frontal gyrus; ; Brodmann area 23; ; postcentral gyrus; ; dorsolateral prefrontal cortex; ; endothelial cell; ; Brodmann area 46;
	Top expressed in
	Region I of hippocampus proper; ; mammillary body; ; prefrontal cortex; ; primary motor cortex; ; subiculum; ; piriform cortex; ; ventral tegmental area; ; dorsal tegmental nucleus; ; superior colliculus; ; amygdala;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	peptidase inhibitor activity; serine-type endopeptidase inhibitor activity;
Cellular component	extracellular region; extracellular exosome; secretory granule lumen; neuronal cell body; cytoplasmic vesicle lumen; extracellular space; cytoplasmic vesicle; perikaryon;
Biological process	central nervous system development; negative regulation of peptidase activity; regulation of cell adhesion; peripheral nervous system development; negative regulation of endopeptidase activity; positive regulation of neuron projection development;
	Sources:Amigo / QuickGO
Orthologs
	5274
	20713
	ENSG00000163536
	ENSMUSG00000027834
	Q99574
	O35684
	NM_005025; NM_001122752
	NM_009250; NM_001357514
	NP_001116224; NP_005016
	NP_033276; NP_001344443
	Wikidata
View/Edit Human	View/Edit Mouse

Neuroserpin is a protein that in humans is encoded by the SERPINI1 gene.

It is associated with Familial encephalopathy with neuroserpin inclusion bodies.

Serine protease inhibitors of the serpin superfamily are involved in many cellular processes. Neuroserpin was first identified as a protein secreted from the axons of dorsal root ganglion neurons (Stoeckli et al., 1989). It is expressed in the late stages of neurogenesis during the process of synapse formation.[supplied by OMIM]

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