Nandrolone decanoate

Nandrolone decanoate
Clinical data
Trade names	Rolon, others
Other names	• Nandrolone decylate; • 19-Nortestosterone 17β-decanoate
Pregnancy; category	AU: D;
Routes of; administration	Intramuscular injection, subcutaneous injection
Drug class	Androgen; Anabolic steroid; Androgen ester; Progestogen
Legal status
Legal status	AU: S4 (Prescription only); CA: Schedule IV; UK: Class C; US: Schedule III;
Pharmacokinetic data
Bioavailability	Intramuscular: 53–73%
Metabolism	Blood (hydrolysis), liver (reduction)
Metabolites	• Nandrolone; • 5α-Dihydronandrolone; • 19-Norandrosterone; • 19-Noretiocholanolone; • Conjugates
Elimination half-life	• Intramuscular: 6–12 days; • Nandrolone: <4.3 hours
Duration of action	• Intramuscular: 2–3 weeks
Excretion	Urine
Identifiers
	IUPAC name [(8R,9S,10R,13S,14S,17S)-13-methyl-3-oxo-2,6,7,8,9,10,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl] decanoate;
CAS Number	360-70-3;
PubChem CID	9677;
DrugBank	DB08804;
ChemSpider	9296;
UNII	H45187T098;
CompTox Dashboard (EPA)	DTXSID7023352 ;
ECHA InfoCard	100.006.037
Chemical and physical data
Formula	C28H44O3
Molar mass	428.657 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCCCCCCCCC(=O)O[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CCC4=CC(=O)CC[C@H]34)C;
	InChI InChI=1S/C28H44O3/c1-3-4-5-6-7-8-9-10-27(30)31-26-16-15-25-24-13-11-20-19-21(29)12-14-22(20)23(24)17-18-28(25,26)2/h19,22-26H,3-18H2,1-2H3/t22-,23+,24+,25-,26-,28-/m0/s1; Key:JKWKMORAXJQQSR-MOPIKTETSA-N;

Nandrolone decanoate, sold under the brand name ROLON among others, is an androgen and anabolic steroid (AAS) medication which is used primarily in the treatment of anemias and wasting syndromes, as well as osteoporosis in menopausal women. It is given by injection into muscle or fat once every one to four weeks.

Side effects of nandrolone decanoate may include symptoms of masculinization like acne, increased hair growth, and voice changes. The medication is a synthetic androgen and anabolic steroid and hence is an agonist of the androgen receptor (AR), the biological target of androgens like testosterone and dihydrotestosterone (DHT). It has strong anabolic effects and weak androgenic effects, which give it a mild side effect profile and make it especially suitable for use in women and children. Nandrolone decanoate is a nandrolone ester and a long-lasting prodrug of nandrolone in the body.

Nandrolone decanoate was first described in 1960 and was introduced for medical use in 1962. It was the second nandrolone ester to be introduced, following nandrolone phenylpropionate (NPP) in 1959, and is one of the most widely used nandrolone esters. It is also one of the most widely used AAS worldwide. In addition to its medical use, nandrolone decanoate is used to improve physique and performance, and is said to be the most widely used AAS for such purposes. The drug is a controlled substance in many countries and so non-medical use is generally illicit.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.