Nalmefene

Nalmefene
Clinical data
Trade names	Selincro, Revex, others
Other names	Nalmetrene; 6-Desoxy-6-methylenenaltrexone; CPH-101; JF-1; Lu AA36143; NIH-10365; ORF-11676
AHFS/Drugs.com	Monograph
MedlinePlus	a605043
License data	EU EMA: by INN; US DailyMed: Nalmefene; US FDA: Nalmefene;
Routes of; administration	By mouth, intranasal, intramuscular injection, intravenous injection, subcutaneous
Drug class	Opioid antagonist
ATC code	N07BB05 (WHO) ;
Legal status
Legal status	AU: S4 (Prescription only); UK: POM (Prescription only); US: ℞-only; EU: Rx-only;
Pharmacokinetic data
Bioavailability	40–50% (orally)
Protein binding	45%
Metabolism	Liver
Elimination half-life	10.8 ± 5.2 hours
Excretion	Kidney
Identifiers
	IUPAC name 17-Cyclopropylmethyl-4,5α-epoxy-6-methylenemorphinan-3,14-diol;
CAS Number	55096-26-9 ; as HCl: 58895-64-0;
PubChem CID	5284594;
IUPHAR/BPS	1628;
DrugBank	DB06230; as HCl: DBSALT001446;
ChemSpider	4447642 ; as HCl: 4534959;
UNII	TOV02TDP9I; as HCl: K7K69QC05X;
KEGG	D05111; as HCl: D02104;
ChEBI	CHEBI:7457;
ChEMBL	ChEMBL982 ; as HCl: ChEMBL1201152;
CompTox Dashboard (EPA)	DTXSID8023347 ;
ECHA InfoCard	100.164.948
Chemical and physical data
Formula	C21H25NO3
Molar mass	339.435 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES OC(C1=C2[C@@]34[C@H]5O1)=CC=C2C[C@@H](N(CC4)CC6CC6)[C@]3(O)CCC5=C;
	InChI InChI=1S/C21H25NO3/c1-12-6-7-21(24)16-10-14-4-5-15(23)18-17(14)20(21,19(12)25-18)8-9-22(16)11-13-2-3-13/h4-5,13,16,19,23-24H,1-3,6-11H2/t16-,19+,20+,21-/m1/s1 ; Key:WJBLNOPPDWQMCH-MBPVOVBZSA-N ;
	(verify)

Nalmefene is a medication that is used in the treatment of opioid overdose and alcohol dependence. Nalmefene belongs to the class of opioid antagonists and can be taken by mouth, administered by injection, or delivered through nasal administration.

In terms of its chemical structure and biological activity, nalmefene is similar to another opioid antagonist called naltrexone, as they are both derivatives of opiates. However, nalmefene offers certain advantages over naltrexone. These include a longer elimination half-life, which means it stays in the body for a longer duration, improved absorption when taken by mouth, and no observed liver toxicity that is dependent on the dosage.

Nalmefene is available as a generic medication.

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