Nadolol

Nadolol
Clinical data
Trade names	Corgard, others
AHFS/Drugs.com	Monograph
MedlinePlus	a682666
License data	US DailyMed: Nadolol;
Routes of; administration	By mouth
Drug class	Beta blocker
ATC code	C07AA12 (WHO) ;
Legal status
Legal status	UK: POM (Prescription only); US: WARNINGRx-only;
Pharmacokinetic data
Protein binding	30%
Metabolism	Not metabolised
Elimination half-life	14-24 hours
Excretion	Renal and fecal (unchanged)
Identifiers
	IUPAC name * rel-(2R,3S)-5-{[(2R)-3-(tert-butylamino)-2-hydroxypropyl]oxy}-1,2,3,4-tetrahydronaphthalene-2,3-diol (2R,3S)-5-{[(2R*)-3-(tert-butylamino)-2-hydroxypropyl]oxy}-1,2,3,4-tetrahydronaphthalene-2,3-diol; ;
CAS Number	42200-33-9 ;
PubChem CID	39147;
IUPHAR/BPS	554;
DrugBank	DB01203 ;
ChemSpider	35815 ;
UNII	FEN504330V;
KEGG	D00432 ;
ChEMBL	ChEMBL649 ;
CompTox Dashboard (EPA)	DTXSID3023342 ;
ECHA InfoCard	100.050.625
Chemical and physical data
Formula	C17H27NO4
Molar mass	309.406 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES OC(CNC(C)(C)C)COc1cccc2c1C[C@H](O)[C@H](O)C2;
	InChI InChI=1S/C17H27NO4/c1-17(2,3)18-9-12(19)10-22-16-6-4-5-11-7-14(20)15(21)8-13(11)16/h4-6,12,14-15,18-21H,7-10H2,1-3H3/t12?,14-,15+/m1/s1 ; Key:VWPOSFSPZNDTMJ-UCWKZMIHSA-N ;
	(verify)

Nadolol, sold under the brand name Corgard among others, is a medication used to treat high blood pressure, heart pain, atrial fibrillation, and some inherited arrhythmic syndromes. It has also been used to prevent migraine headaches and complications of cirrhosis. It is taken orally.

Common side effects include dizziness, feeling tired, a slow heart rate, and Raynaud syndrome. Serious side effects may include heart failure and bronchospasm. Its use in pregnancy and breastfeeding is of unclear safety. It is a non-selective beta blocker and works by blocking β1-adrenergic receptors in the heart and β2-adrenergic receptors in blood vessels.

Nadolol was patented in 1970 and came into medical use in 1978. It is available as a generic medication. In 2020, it was the 340th most commonly prescribed medication in the United States, with more than 700 thousand prescriptions.

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