NRXN1

NRXN1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3B3Q
Identifiers
Aliases	NRXN1, Hs.22998, PTHSL2, SCZD17, neurexin 1
External IDs	OMIM: 600565 MGI: 1096391 HomoloGene: 21005 GeneCards: NRXN1
Gene location (Human)
Chr.	Chromosome 2 (human)
End	51,225,575 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	91,093,071 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; middle temporal gyrus; ; superior frontal gyrus; ; parietal lobe; ; postcentral gyrus; ; Brodmann area 23; ; entorhinal cortex; ; dorsolateral prefrontal cortex; ; Brodmann area 9; ; Brodmann area 46;
	Top expressed in
	medial dorsal nucleus; ; medial geniculate nucleus; ; lateral geniculate nucleus; ; cingulate gyrus; ; primary motor cortex; ; dentate gyrus; ; prefrontal cortex; ; piriform cortex; ; subiculum; ; cerebellar vermis;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	metal ion binding; calcium-dependent protein binding; neuroligin family protein binding; signaling receptor binding; transmembrane signaling receptor activity; cell adhesion molecule binding; protein binding; type 1 fibroblast growth factor receptor binding; calcium ion binding; acetylcholine receptor binding; calcium channel regulator activity; signaling receptor activity;
Cellular component	integral component of membrane; vesicle; nuclear membrane; membrane; endocytic vesicle; axonal growth cone; synapse; cell surface; cell junction; neuronal cell body; endoplasmic reticulum; presynaptic membrane; plasma membrane; integral component of presynaptic membrane; presynapse; integral component of plasma membrane; nucleolus; protein-containing complex; Schaffer collateral - CA1 synapse; glutamatergic synapse; GABA-ergic synapse; integral component of presynaptic active zone membrane;
Biological process	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; receptor localization to synapse; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; NMDA glutamate receptor clustering; establishment of protein localization; neuron cell-cell adhesion; gamma-aminobutyric acid receptor clustering; neuronal signal transduction; gephyrin clustering involved in postsynaptic density assembly; postsynaptic density protein 95 clustering; learning; regulation of AMPA receptor activity; negative regulation of filopodium assembly; presynaptic membrane assembly; regulation of NMDA receptor activity; vocalization behavior; neuroligin clustering involved in postsynaptic membrane assembly; adult behavior; positive regulation of synaptic transmission, glutamatergic; postsynaptic membrane assembly; cell adhesion; angiogenesis; positive regulation of excitatory postsynaptic potential; social behavior; guanylate kinase-associated protein clustering; synapse assembly; protein-containing complex assembly involved in synapse maturation; synaptic vesicle clustering; protein localization to synapse; signal transduction; cerebellar granule cell differentiation; positive regulation of synapse assembly; positive regulation of presynaptic active zone assembly; positive regulation of protein localization to plasma membrane; positive regulation of gene expression; negative regulation of gene expression; positive regulation of protein kinase A signaling; neuron projection development; positive regulation of peptidyl-serine phosphorylation; positive regulation of fibroblast growth factor receptor signaling pathway; positive regulation of protein kinase B signaling; positive regulation of ERK1 and ERK2 cascade; cellular response to calcium ion; positive regulation of protein kinase C activity; vocal learning; chemical synaptic transmission; regulation of insulin secretion involved in cellular response to glucose stimulus; axon guidance; prepulse inhibition; neuromuscular process controlling balance; positive regulation of synapse maturation; neurotransmitter secretion; regulation of grooming behavior; synaptic membrane adhesion; regulation of synaptic vesicle cycle; regulation of postsynaptic specialization assembly; regulation of presynapse assembly; regulation of postsynaptic density assembly; trans-synaptic signaling by endocannabinoid;
	Sources:Amigo / QuickGO
Orthologs
	9378
	18189
	ENSG00000179915
	ENSMUSG00000024109
	P58400; Q9ULB1; Q49A31
	P0DI97; Q9CS84
NM_001135659; NM_004801; NM_138735; NM_001320156; NM_001320157;
	NM_001330077; NM_001330078; NM_001330079; NM_001330081; NM_001330082; NM_001330083; NM_001330084; NM_001330085; NM_001330086; NM_001330087; NM_001330088; NM_001330089; NM_001330090; NM_001330091; NM_001330092; NM_001330093; NM_001330094; NM_001330095; NM_001330096; NM_001330097
NM_020252; NM_177284; NM_001346957; NM_001346958; NM_001346959;
	NM_001346960; NM_001346961; NM_001346962; NM_001347419
NP_001129131; NP_001307085; NP_001307086; NP_001317006; NP_001317007;
	NP_001317008; NP_001317010; NP_001317011; NP_001317012; NP_001317013; NP_001317014; NP_001317015; NP_001317016; NP_001317017; NP_001317018; NP_001317019; NP_001317020; NP_001317021; NP_001317022; NP_001317023; NP_001317024; NP_001317025; NP_001317026; NP_004792; NP_620072; NP_001129131.1; NP_004792.1; NP_620072.1; NP_004792.1; NP_004792.1; NP_620072.1
NP_001333886; NP_001333887; NP_001333888; NP_001333889; NP_001333890;
	NP_001333891; NP_001334348; NP_064648; NP_796258; NP_001390248; NP_001390249; NP_001390250; NP_001390251; NP_001390252; NP_001390253; NP_001390254; NP_001390255; NP_001390256; NP_001390257; NP_001390258; NP_001390259; NP_001390260; NP_001390261; NP_064648.3; NP_796258.2
	Wikidata
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Neurexin-1-alpha is a protein that in humans is encoded by the NRXN1 gene.

Neurexins are a family of proteins that function in the vertebrate nervous system as cell adhesion molecules and receptors. They are encoded by several unlinked genes of which two, NRXN1 and NRXN3, are among the largest known human genes. Three of the genes (NRXN1-3) utilize two alternate promoters and include numerous alternatively spliced exons to generate thousands of distinct mRNA transcripts and protein isoforms. The majority of transcripts are produced from the upstream promoter and encode alpha-neurexin isoforms; a much smaller number of transcripts are produced from the downstream promoter and encode beta-neurexin isoforms. The alpha-neurexins contain epidermal growth factor-like (EGF-like) sequences and laminin G domains, and have been shown to interact with neurexophilins. The beta-neurexins lack EGF-like sequences and contain fewer laminin G domains than alpha-neurexins.

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