NRCAM

NRCAM
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1UEN, 1UEY
Identifiers
Aliases	NRCAM, neuronal cell adhesion molecule
External IDs	OMIM: 601581 MGI: 104750 HomoloGene: 21041 GeneCards: NRCAM
Gene location (Human)
Chr.	Chromosome 7 (human)
End	108,456,717 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	44,601,964 bp
RNA expression pattern
	Top expressed in
	Brodmann area 23; ; middle temporal gyrus; ; Brodmann area 9; ; prefrontal cortex; ; superior frontal gyrus; ; entorhinal cortex; ; amygdala; ; pons; ; endothelial cell; ; parietal lobe;
	Top expressed in
	subiculum; ; medial dorsal nucleus; ; superior frontal gyrus; ; prefrontal cortex; ; median eminence; ; arcuate nucleus; ; hippocampus proper; ; habenula; ; substantia nigra; ; olfactory bulb;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; protein binding involved in heterotypic cell-cell adhesion; ankyrin binding;
Cellular component	integral component of membrane; cell projection; membrane; plasma membrane; synapse; integral component of plasma membrane; extracellular region; axon; neuron projection; axon initial segment; external side of plasma membrane; glutamatergic synapse; integral component of postsynaptic membrane; integral component of postsynaptic density membrane;
Biological process	protein localization; clustering of voltage-gated sodium channels; regulation of neuron projection development; regulation of axon extension; axonogenesis; heterotypic cell-cell adhesion; neuron migration; central nervous system development; cell adhesion; neuronal action potential propagation; angiogenesis; positive regulation of neuron differentiation; synapse assembly; axonal fasciculation; retinal ganglion cell axon guidance; axon guidance; cell-cell adhesion; regulation of postsynapse organization;
	Sources:Amigo / QuickGO
Orthologs
	4897
	319504
	ENSG00000091129
	ENSMUSG00000020598
	Q92823
	Q810U4
NM_001037132; NM_001037133; NM_001193582; NM_001193583; NM_001193584;
	NM_005010
	NM_001146031; NM_176930
NP_001032209; NP_001180511; NP_001180512; NP_001180513; NP_005001;
	NP_001358048; NP_001358051; NP_001358052; NP_001358053; NP_001358054; NP_001358055; NP_001358056; NP_001358057; NP_001358058; NP_001358059; NP_001358060; NP_001358061; NP_001358062; NP_001358063; NP_001358064; NP_001358065; NP_001358066; NP_001358067; NP_001358068; NP_001358069; NP_001358070; NP_001358071; NP_001358072; NP_001358073; NP_001358074; NP_001358075; NP_001358076; NP_001358077; NP_001358078; NP_001358079; NP_001358080; NP_001358081; NP_001358082; NP_001358083; NP_001358084; NP_001358085; NP_001358086; NP_001358087; NP_001358088; NP_001358089; NP_001358090; NP_001358091; NP_001358092; NP_001358093; NP_001358094; NP_001358095; NP_001358096; NP_001358097; NP_001358098; NP_001358099; NP_001358100; NP_001358101; NP_001358102; NP_001358103; NP_001358104; NP_001358105; NP_001358106; NP_001358107; NP_001358108; NP_001358109; NP_001358110; NP_001358111
	NP_001139503; NP_795904
	Wikidata
View/Edit Human	View/Edit Mouse

Neuronal cell adhesion molecule is a protein that in humans is encoded by the NRCAM gene.

Cell adhesion molecules (CAMs) are members of the immunoglobulin superfamily. This gene encodes a neuronal cell adhesion molecule with multiple immunoglobulin-like C2-type domains and fibronectin type-III domains. This ankyrin-binding protein is involved in neuron-neuron adhesion and promotes directional signaling during axonal cone growth. This gene is also expressed in non-neural tissues and may play a general role in cell-cell communication via signaling from its intracellular domain to the actin cytoskeleton during directional cell migration. Allelic variants of this gene have been associated with autism and addiction vulnerability. Alternative splicing results in multiple transcript variants encoding different isoforms.

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