NPEPPS

NPEPPS
Identifiers
Aliases	NPEPPS, AAP-S, MP100, PSA, aminopeptidase puromycin sensitive
External IDs	OMIM: 606793 MGI: 1101358 HomoloGene: 36199 GeneCards: NPEPPS
Gene location (Human)
Chr.	Chromosome 17 (human)
End	47,624,665 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	97,171,464 bp
RNA expression pattern
	Top expressed in
	vagina; ; ganglionic eminence; ; gastric mucosa; ; skin of abdomen; ; right uterine tube; ; gastrocnemius muscle; ; minor salivary gland; ; left adrenal gland; ; canal of the cervix; ; stromal cell of endometrium;
	Top expressed in
	retinal pigment epithelium; ; ciliary body; ; facial motor nucleus; ; supraoptic nucleus; ; anterior horn of spinal cord; ; epithelium of stomach; ; soleus muscle; ; lacrimal gland; ; olfactory bulb; ; ganglionic eminence;
	More reference expression data
	n/a
Gene ontology
Molecular function	peptide binding; zinc ion binding; peptidase activity; metalloaminopeptidase activity; metallopeptidase activity; hydrolase activity; metal ion binding; aminopeptidase activity;
Cellular component	extracellular exosome; nucleus; cytosol; cytoplasm;
Biological process	protein polyubiquitination; cellular response to hypoxia; positive regulation of protein targeting to mitochondrion; peptide catabolic process; proteolysis;
	Sources:Amigo / QuickGO
Orthologs
	9520
	19155
	ENSG00000141279
	ENSMUSG00000001441
	P55786
	Q11011
	NM_006310; NM_001330257
	NM_008942
	NP_001317186; NP_006301
	NP_032968
	Wikidata
View/Edit Human	View/Edit Mouse

Puromycin-sensitive amino peptidase also known as cytosol alanyl aminopeptidase or alanine aminopeptidase (AAP) (EC 3.4.11.14) is an enzyme that in humans is encoded by the NPEPPS gene. It is used as a biomarker to detect damage to the kidneys, and that may be used to help diagnose certain kidney disorders. It is found at high levels in the urine when there are kidney problems.

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