NOX1

NOX1
Identifiers
Aliases	NOX1, GP91-2, MOX1, NOH-1, NOH1, NADPH oxidase 1, NOH-1L
External IDs	OMIM: 300225 MGI: 2450016 HomoloGene: 48495 GeneCards: NOX1
Gene location (Human)
Chr.	X chromosome (human)
End	100,874,359 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	133,122,705 bp
RNA expression pattern
	Top expressed in
	rectum; ; pancreatic ductal cell; ; appendix; ; smooth muscle tissue; ; palpebral conjunctiva; ; seminal vesicula; ; metanephros; ; gallbladder; ; hypothalamus; ; cerebellar hemisphere;
	Top expressed in
	ileum; ; duodenum; ; colon; ; jejunum; ; secondary oocyte; ; embryo; ; lung; ; quadriceps femoris muscle; ; cerebellar cortex; ; thymus;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	metal ion binding; voltage-gated ion channel activity; protein binding; NADP binding; oxidoreductase activity; superoxide-generating NAD(P)H oxidase activity;
Cellular component	cytoplasm; integral component of membrane; endosome; cell projection; membrane; plasma membrane; cell junction; NADPH oxidase complex; early endosome;
Biological process	cellular stress response to acidic pH; NADP metabolic process; intracellular pH elevation; cellular response to hyperoxia; regulation of ion transmembrane transport; extracellular matrix organization; positive regulation of JNK cascade; oxygen metabolic process; ion transport; positive regulation of integrin biosynthetic process; regulation of blood pressure; respiratory burst; hydrogen peroxide metabolic process; angiogenesis; positive regulation of cell population proliferation; positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; positive regulation of vascular endothelial growth factor production; inflammatory response; regulation of systemic arterial blood pressure by renin-angiotensin; cell migration; signal transduction; positive regulation of smooth muscle cell proliferation; positive regulation of MAPK cascade; ion transmembrane transport; superoxide anion generation; defense response;
	Sources:Amigo / QuickGO
Orthologs
	27035
	237038
	ENSG00000007952
	ENSMUSG00000031257
	Q9Y5S8
	Q8CIZ9
	NM_013955; NM_001271815; NM_007052; NM_013954
	NM_172203
	NP_001258744; NP_008983; NP_039249
	NP_757340
	Wikidata
View/Edit Human	View/Edit Mouse

NADPH oxidase 1 is an enzyme that in humans is encoded by the NOX1 gene.

NOX1 is a homolog of the catalytic subunit of the superoxide-generating NADPH oxidase of phagocytes, gp91phox. Two transcript variants encoding different isoforms have been found for this gene.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.