Notch 2

NOTCH2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2OO4
Identifiers
Aliases	NOTCH2, AGS2, HJCYS, hN2, Notch-2, notch 2, notch receptor 2
External IDs	OMIM: 600275 MGI: 97364 HomoloGene: 7865 GeneCards: NOTCH2
Gene location (Human)
Chr.	Chromosome 1 (human)
End	120,100,779 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	98,057,677 bp
RNA expression pattern
	Top expressed in
	retinal pigment epithelium; ; synovial joint; ; caput epididymis; ; vulva; ; lactiferous duct; ; corpus epididymis; ; cavity of mouth; ; spongy bone; ; periodontal fiber; ; visceral pleura;
	Top expressed in
	ciliary body; ; retinal pigment epithelium; ; aortic valve; ; ascending aorta; ; vas deferens; ; cumulus cell; ; conjunctival fornix; ; molar; ; internal carotid artery; ; external carotid artery;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; protein binding; signaling receptor activity;
Cellular component	cytoplasm; integral component of membrane; endoplasmic reticulum membrane; membrane; Golgi membrane; receptor complex; plasma membrane; integral component of plasma membrane; nucleoplasm; extracellular region; cell surface; nucleus;
Biological process	Notch signaling pathway; cell differentiation; hemopoiesis; pulmonary valve morphogenesis; regulation of transcription, DNA-templated; positive regulation of Ras protein signal transduction; negative regulation of apoptotic process; marginal zone B cell differentiation; transcription, DNA-templated; nervous system development; stem cell population maintenance; multicellular organism development; atrial septum morphogenesis; regulation of developmental process; bone remodeling; animal organ morphogenesis; transcription initiation from RNA polymerase II promoter; Notch signaling involved in heart development; apoptotic process; cell fate determination; intracellular receptor signaling pathway; negative regulation of gene expression; negative regulation of growth rate; positive regulation of ERK1 and ERK2 cascade; regulation of osteoclast development; positive regulation of keratinocyte proliferation; regulation of actin cytoskeleton reorganization;
	Sources:Amigo / QuickGO
Orthologs
	4853
	18129
	ENSG00000134250
	ENSMUSG00000027878
	Q04721
	O35516
	NM_001200001; NM_024408
	NM_010928
	NP_001186930; NP_077719
	NP_035058
	Wikidata
View/Edit Human	View/Edit Mouse

Neurogenic locus notch homolog protein 2 (Notch 2) is a protein that in humans is encoded by the NOTCH2 gene.

NOTCH2 is associated with Alagille syndrome and Hajdu–Cheney syndrome.

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