NLRP1

NLRP1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1PN5, 3KAT, 4IFP, 4IM6
Identifiers
Aliases	NLRP1, CARD7, CIDED, CLR17.1, DEFCAP, DEFCAP-L/S, NAC, NALP1, PP1044, SLEV1, VAMAS1, NLR family, pyrin domain containing 1, NLR family pyrin domain containing 1, MSPC, AIADK, JRRP
External IDs	OMIM: 606636 MGI: 3582959 HomoloGene: 19080 GeneCards: NLRP1
Gene location (Human)
Chr.	Chromosome 17 (human)
End	5,619,424 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	71,121,559 bp
RNA expression pattern
	Top expressed in
	monocyte; ; blood; ; skin of abdomen; ; spleen; ; lymph node; ; right lung; ; appendix; ; bone marrow cells; ; vagina; ; ascending aorta;
	Top expressed in
	jejunum; ; ileum; ; colon; ; duodenum; ; zone of skin; ; lip; ; spleen; ; ovary; ; thymus; ; quadriceps femoris muscle;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein domain specific binding; nucleotide binding; cysteine-type endopeptidase activator activity involved in apoptotic process; ATP binding; enzyme binding; protein binding;
Cellular component	cytoplasm; inflammasome complex; nucleus; intracellular anatomical structure; nucleoplasm; cytosol; NLRP1 inflammasome complex;
Biological process	neuron apoptotic process; regulation of apoptotic process; activation of cysteine-type endopeptidase activity involved in apoptotic process; response to muramyl dipeptide; apoptotic process; defense response to bacterium; regulation of inflammatory response; immune system process; inflammatory response; innate immune response; viral process; NLRP1 inflammasome complex assembly; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process;
	Sources:Amigo / QuickGO
Orthologs
	22861
	637515
	ENSG00000091592
	ENSMUSG00000070390
	Q9C000
	Q2LKV5; Q2LKV2; Q2LKW6; Q0GKD5
	NM_033007; NM_001033053; NM_014922; NM_033004; NM_033006
	NM_001039680; NM_001040696; NM_001162414
	NP_001028225; NP_055737; NP_127497; NP_127499; NP_127500
	NP_001035786; NP_001155886
	Wikidata
View/Edit Human	View/Edit Mouse

NLRP1 encodes NACHT, LRR, FIIND, CARD domain and PYD domains-containing protein 1 in humans. NLRP1 was the first protein shown to form an inflammasome. NLRP1 is expressed by a variety of cell types, which are predominantly epithelial or hematopoietic. The expression is also seen within glandular epithelial structures including the lining of the small intestine, stomach, airway epithelia and in hairless or glabrous skin. NLRP1 polymorphisms are associated with skin extra-intestinal manifestations in CD. Its highest expression was detected in human skin, in psoriasis and in vitiligo. Polymorphisms of NLRP1 were found in lupus erythematosus and diabetes type 1. Variants of mouse NLRP1 were found to be activated upon N-terminal cleavage by the protease in anthrax lethal factor.

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