NLGN3

NLGN3
Identifiers
Aliases	NLGN3, HNL3, neuroligin 3
External IDs	OMIM: 300336 MGI: 2444609 HomoloGene: 23133 GeneCards: NLGN3
Gene location (Human)
Chr.	X chromosome (human)
End	71,175,255 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	100,369,569 bp
RNA expression pattern
	Top expressed in
	prefrontal cortex; ; amygdala; ; ganglionic eminence; ; cingulate gyrus; ; nucleus accumbens; ; caudate nucleus; ; Brodmann area 9; ; putamen; ; internal globus pallidus; ; hippocampus proper;
	Top expressed in
	visual cortex; ; superior frontal gyrus; ; supraoptic nucleus; ; substantia nigra; ; Region I of hippocampus proper; ; hippocampus proper; ; neural tube; ; piriform cortex; ; olfactory tubercle; ; temporal lobe;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	scaffold protein binding; neurexin family protein binding; carboxylic ester hydrolase activity; cell adhesion molecule binding; protein binding; signaling receptor activity;
Cellular component	integral component of membrane; membrane; cell surface; synapse; cell junction; endocytic vesicle; excitatory synapse; plasma membrane; integral component of plasma membrane; integral component of postsynaptic membrane; spanning component of membrane; presynapse; symmetric, GABA-ergic, inhibitory synapse; asymmetric, glutamatergic, excitatory synapse;
Biological process	regulation of AMPA receptor activity; positive regulation of synaptic vesicle clustering; social behavior; rhythmic synaptic transmission; regulation of NMDA receptor activity; regulation of synaptic transmission, glutamatergic; excitatory postsynaptic potential; positive regulation of AMPA receptor activity; synapse organization; negative regulation of excitatory postsynaptic potential; modulation of chemical synaptic transmission; regulation of respiratory gaseous exchange by nervous system process; axon extension; learning; long-term potentiation; vocalization behavior; negative regulation of dendritic spine morphogenesis; neuron cell-cell adhesion; regulation of dendritic spine morphogenesis; receptor-mediated endocytosis; cell adhesion; oligodendrocyte differentiation; regulation of terminal button organization; adult behavior; positive regulation of excitatory postsynaptic potential; positive regulation of synaptic transmission, glutamatergic; regulation of long-term synaptic potentiation; visual learning; inhibitory postsynaptic potential; positive regulation of synapse assembly; synapse assembly; synaptic vesicle endocytosis; postsynaptic membrane assembly; presynaptic membrane assembly; presynapse assembly;
	Sources:Amigo / QuickGO
Orthologs
	54413
	245537
	ENSG00000196338
	ENSMUSG00000031302
	Q9NZ94
	Q8BYM5
	NM_001166660; NM_018977; NM_181303; NM_001321276
	NM_172932
	NP_001160132; NP_001308205; NP_061850; NP_851820; NP_001160132.1
	NP_766520
	Wikidata
View/Edit Human	View/Edit Mouse

Neuroligin-3 is a protein that in humans is encoded by the NLGN3 gene.

This gene encodes a member of the neuroligin family of neuronal cell surface proteins. Neuroligins may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. Mutations in this gene may be associated with autism spectrum disorders (ASDs). Multiple transcript variants encoding distinct isoforms have been identified for this gene, but their full length sequences have not been determined.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.