NLGN2

NLGN2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3BL8
Identifiers
Aliases	NLGN2, neuroligin 2
External IDs	OMIM: 606479 MGI: 2681835 HomoloGene: 69317 GeneCards: NLGN2
Gene location (Human)
Chr.	Chromosome 17 (human)
End	7,419,860 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	69,728,610 bp
RNA expression pattern
	Top expressed in
	superior frontal gyrus; ; ganglionic eminence; ; stromal cell of endometrium; ; nucleus accumbens; ; caudate nucleus; ; myometrium; ; left uterine tube; ; putamen; ; prefrontal cortex; ; Brodmann area 9;
	Top expressed in
	subiculum; ; dorsomedial hypothalamic nucleus; ; piriform cortex; ; superior colliculus; ; internal carotid artery; ; superior frontal gyrus; ; cerebellar cortex; ; cerebellar vermis; ; habenula; ; primary motor cortex;
	More reference expression data
	n/a
Gene ontology
Molecular function	carboxylic ester hydrolase activity; neurexin family protein binding; cell adhesion molecule binding; signaling receptor activity; identical protein binding;
Cellular component	integral component of membrane; postsynaptic membrane; membrane; synapse; inhibitory synapse; cell surface; cell junction; presynaptic membrane; plasma membrane; integral component of plasma membrane; integral component of postsynaptic membrane; intracellular anatomical structure; spanning component of membrane; glycinergic synapse; dopaminergic synapse; GABA-ergic synapse; symmetric, GABA-ergic, inhibitory synapse; integral component of postsynaptic specialization membrane;
Biological process	neuromuscular process controlling balance; neuron cell-cell adhesion; positive regulation of inhibitory postsynaptic potential; synapse organization; modulation of chemical synaptic transmission; positive regulation of protein localization to synapse; gephyrin clustering involved in postsynaptic density assembly; postsynaptic density protein 95 clustering; positive regulation of synaptic transmission, GABAergic; regulation of AMPA receptor activity; locomotory exploration behavior; regulation of respiratory gaseous exchange by nervous system process; cell-cell junction maintenance; positive regulation of synaptic vesicle clustering; positive regulation of synaptic transmission, glutamatergic; cell adhesion; positive regulation of excitatory postsynaptic potential; sensory perception of pain; terminal button organization; protein localization to synapse; positive regulation of insulin secretion; positive regulation of synapse assembly; inhibitory synapse assembly; synapse assembly; synaptic vesicle endocytosis; postsynaptic membrane assembly; presynaptic membrane assembly; cell-cell adhesion; postsynaptic specialization assembly; presynapse assembly;
	Sources:Amigo / QuickGO
Orthologs
	57555
	216856
	ENSG00000169992; ENSG00000283859
	ENSMUSG00000051790
	Q8NFZ4
	Q69ZK9
	NM_020795
	NM_198862; NM_001364137
	NP_065846
	NP_942562; NP_001351066
	Wikidata
View/Edit Human	View/Edit Mouse

Neuroligin-2 is a protein that in humans is encoded by the NLGN2 gene.

This gene encodes a member of a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses.

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