NLGN1

NLGN1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3B3Q
Identifiers
Aliases	NLGN1, NL1, neuroligin 1
External IDs	OMIM: 600568 MGI: 2179435 HomoloGene: 56690 GeneCards: NLGN1
Gene location (Human)
Chr.	Chromosome 3 (human)
End	174,294,372 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	26,386,609 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; sural nerve; ; Achilles tendon; ; ganglionic eminence; ; stromal cell of endometrium; ; entorhinal cortex; ; corpus callosum; ; prefrontal cortex; ; postcentral gyrus; ; superior frontal gyrus;
	Top expressed in
	olfactory tubercle; ; piriform cortex; ; substantia nigra; ; dentate gyrus; ; ventromedial nucleus; ; globus pallidus; ; primary motor cortex; ; paraventricular nucleus of hypothalamus; ; prefrontal cortex; ; subiculum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	PDZ domain binding; protein dimerization activity; cell adhesion molecule binding; scaffold protein binding; carboxylic ester hydrolase activity; neurexin family protein binding; amyloid-beta binding; signaling receptor activity;
Cellular component	synapse; integral component of membrane; NMDA selective glutamate receptor complex; Golgi apparatus; cell junction; dendritic shaft; filopodium tip; dendritic spine; postsynaptic membrane; membrane; dendrite; excitatory synapse; external side of plasma membrane; cell surface; presynapse; postsynaptic density; plasma membrane; integral component of postsynaptic membrane; integral component of plasma membrane; spanning component of membrane; postsynapse; glutamatergic synapse; asymmetric, glutamatergic, excitatory synapse; integral component of postsynaptic specialization membrane;
Biological process	NMDA glutamate receptor clustering; positive regulation of ruffle assembly; positive regulation of synaptic vesicle exocytosis; regulation of AMPA receptor activity; rhythmic process; positive regulation of synaptic transmission, glutamatergic; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; positive regulation of circadian sleep/wake cycle, wakefulness; regulation of respiratory gaseous exchange by nervous system process; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; protein heterotetramerization; synaptic vesicle transport; terminal button organization; synapse organization; positive regulation of synaptic transmission, GABAergic; postsynaptic density protein 95 clustering; receptor localization to synapse; protein localization to synapse; neurexin clustering involved in presynaptic membrane assembly; positive regulation of synaptic vesicle endocytosis; synaptic vesicle targeting; protein homooligomerization; positive regulation of protein localization to synapse; neuron projection development; protein targeting; positive regulation of intracellular signal transduction; long-term potentiation; nervous system development; AMPA glutamate receptor clustering; neuronal signal transduction; synaptic vesicle clustering; positive regulation of synaptic vesicle clustering; cytoskeletal matrix organization at active zone; synapse assembly; establishment of protein localization; modulation of chemical synaptic transmission; positive regulation of filopodium assembly; cell adhesion; regulation of neuron differentiation; neuron cell-cell adhesion; positive regulation of dendritic spine development; regulation of NMDA receptor activity; positive regulation of excitatory postsynaptic potential; negative regulation of dendritic spine morphogenesis; positive regulation of synapse assembly; excitatory synapse assembly; positive regulation of presynaptic active zone assembly; retrograde trans-synaptic signaling by trans-synaptic protein complex; synaptic vesicle endocytosis; postsynaptic membrane assembly; presynaptic membrane assembly; cellular response to calcium ion; postsynaptic specialization assembly; presynapse assembly; regulation of presynapse organization; synaptic membrane adhesion; neuron projection arborization;
	Sources:Amigo / QuickGO
Orthologs
	22871
	192167
	ENSG00000169760
	ENSMUSG00000063887
	Q8N2Q7
	Q99K10
NM_014932; NM_001365923; NM_001365924; NM_001365925; NM_001365926;
	NM_001365927; NM_001365928; NM_001365929; NM_001365930; NM_001365931; NM_001365932; NM_001365933; NM_001365934; NM_001365935; NM_001365936
	NM_001163387; NM_138666; NM_001357095; NM_001357096; NM_001357097
NP_055747; NP_001352852; NP_001352853; NP_001352854; NP_001352855;
	NP_001352856; NP_001352857; NP_001352858; NP_001352859; NP_001352860; NP_001352861; NP_001352862; NP_001352863; NP_001352864; NP_001352865
	NP_001156859; NP_619607; NP_001344024; NP_001344025; NP_001344026
	Wikidata
View/Edit Human	View/Edit Mouse

Neuroligin-1 is a protein that in humans is encoded by the NLGN1 gene.

This gene encodes a member of the neuroligin family of neuronal cell surface proteins. Neuroligin-1 acts as splice site-specific ligand for β-neurexins and has been shown to localize to the postsynaptic compartment at excitatory synapses and is involved in the formation and remodeling of central nervous system synapses.

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