NKG2D

KLRK1
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	1KCG, 4PDC, 1HYR, 1MPU, 4S0U
Identifiers
Aliases	KLRK1, CD314, D12S2489E, KLR, NKG2-D, NKG2D, natural killer group 2D, killer cell lectin-like receptor K1, killer cell lectin like receptor K1
External IDs	OMIM: 611817 HomoloGene: 136440 GeneCards: KLRK1
Gene location (Human)
Chr.	Chromosome 12 (human)
End	10,391,874 bp
RNA expression pattern
	Top expressed in
	spleen; ; lymph node; ; blood; ; appendix; ; gallbladder; ; upper lobe of left lung; ; bone marrow; ; endometrium; ; duodenum; ; right lung;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	protein homodimerization activity; protein binding; MHC class Ib receptor activity; MHC class I protein binding; carbohydrate binding; signaling receptor activity; kinase binding;
Cellular component	integral component of membrane; membrane; integral component of plasma membrane; cell surface; external side of plasma membrane; plasma membrane;
Biological process	cell differentiation; adaptive immune response; immune system process; positive regulation of nitric oxide biosynthetic process; negative regulation of natural killer cell chemotaxis; T cell costimulation; natural killer cell activation; positive regulation of interferon-gamma production; stimulatory C-type lectin receptor signaling pathway; negative regulation of GTPase activity; regulation of immune response; cellular response to lipopolysaccharide; positive regulation of natural killer cell mediated cytotoxicity; signal transduction; defense response to Gram-positive bacterium; innate immune response; natural killer cell mediated cytotoxicity; positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target; positive regulation of myeloid dendritic cell activation; positive regulation of apoptotic process;
	Sources:Amigo / QuickGO
Orthologs
	22914
	n/a
	ENSG00000213809
	n/a
	P26718
	n/a
	NM_007360
	n/a
	NP_001186734
	n/a
	Wikidata
View/Edit Human

NKG2D is an activating receptor (transmembrane protein) belonging to the NKG2 family of C-type lectin-like receptors. NKG2D is encoded by KLRK1 (killer cell lectin like receptor K1) gene which is located in the NK-gene complex (NKC) situated on chromosome 6 in mice and chromosome 12 in humans. In mice, it is expressed by NK cells, NK1.1⁺ T cells, γδ T cells, activated CD8⁺ αβ T cells and activated macrophages. In humans, it is expressed by NK cells, γδ T cells and CD8⁺ αβ T cells. NKG2D recognizes induced-self proteins from MIC and RAET1/ULBP families which appear on the surface of stressed, malignant transformed, and infected cells.

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