N1-Methylpseudouridine
N1-Methylpseudouridine (abbreviated m1Ψ) is a natural archaeal tRNA component, component of mammalian ribosomal RNA, and "hypermodified" pyrimidine nucleoside used in biochemistry and molecular biology for in vitro transcription and is found in the SARS-CoV-2 mRNA vaccines tozinameran (Pfizer–BioNTech) and elasomeran (Moderna).
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IUPAC name
5-[(2S,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1-methylpyrimidine-2,4-dione | |
Other names
1-Methylpseudouridine; m1Ψ | |
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3D model (JSmol) |
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ChEBI | |
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UNII | |
CompTox Dashboard (EPA) |
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Properties | |
C10H14N2O6 | |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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