N-Myc

MYCN
Identifiers
Aliases	MYCN, MODED, N-myc, NMYC, ODED, bHLHe37, v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog, MYCN proto-oncogene, bHLH transcription factor, MYCNsORF, MYCNsPEP
External IDs	OMIM: 164840 MGI: 97357 HomoloGene: 3922 GeneCards: MYCN
Gene location (Human)
Chr.	Chromosome 2 (human)
End	15,947,007 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	12,991,915 bp
RNA expression pattern
	Top expressed in
	embryo; ; ganglionic eminence; ; placenta; ; kidney tubule; ; middle temporal gyrus; ; Brodmann area 23; ; amniotic fluid; ; glomerulus; ; endothelial cell; ; metanephric glomerulus;
	Top expressed in
	primitive streak; ; hair follicle; ; medial ganglionic eminence; ; somite; ; abdominal wall; ; maxillary prominence; ; superior cervical ganglion; ; ectoderm; ; otic placode; ; trigeminal ganglion;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; protein dimerization activity; DNA-binding transcription factor activity; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; kinase binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	chromatin; nucleus; nucleolus;
Biological process	regulation of transcription, DNA-templated; regulation of transcription by RNA polymerase II; transcription, DNA-templated; positive regulation of gene expression; negative regulation of gene expression; positive regulation of production of miRNAs involved in gene silencing by miRNA; transcription by RNA polymerase II; cartilage condensation; positive regulation of mesenchymal cell proliferation; positive regulation of cell population proliferation; positive regulation of cell death; lung development; embryonic digit morphogenesis; regulation of inner ear auditory receptor cell differentiation; positive regulation of transcription, DNA-templated; positive regulation of transcription by RNA polymerase II; embryonic skeletal system morphogenesis; negative regulation of astrocyte differentiation; branching morphogenesis of an epithelial tube; negative regulation of reactive oxygen species metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	4613
	18109
	ENSG00000134323
	ENSMUSG00000037169
	P04198
	P03966
	NM_005378; NM_001293228; NM_001293231; NM_001293233
	NM_008709
	NP_001280157; NP_001280160; NP_001280162; NP_005369
	NP_032735
	Wikidata
View/Edit Human	View/Edit Mouse

N-myc proto-oncogene protein also known as N-Myc or basic helix-loop-helix protein 37 (bHLHe37), is a protein that in humans is encoded by the MYCN gene.

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