Monobactam

Aztreonam
Aztreonam
Drug class
	Aztreonam. (The four-membered ring at the bottom is the β-lactam. There is a second thiazole ring, but it is not fused to the β-lactam ring.)
Class identifiers
Use	Bacterial infection
ATC code	J01DF
External links
MeSH	D008997
Legal status
	In Wikidata

Monobactams are bacterially-produced monocyclic β-lactam antibiotics. The β-lactam ring is not fused to another ring, in contrast to most other β-lactams.

Monobactams are narrow-spectrum antibiotics effective only against aerobic Gram-negative bacilli. Due to their narrow spectrum, monobactams can be used to treat infections by susceptible bacteria without disrupting the patient's microbiota. Monobactams are nevertheless seldom used.

Aztreonam is the principal and sole commercially available member of monobactams. Other monobactams include tigemonam, nocardicin A, and tabtoxin.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.