Mitral regurgitation

Mitral regurgitation (MR), also known as mitral insufficiency or mitral incompetence, is a form of valvular heart disease in which the mitral valve is insufficient and does not close properly when the heart pumps out blood. It is the abnormal leaking of blood backwards – regurgitation from the left ventricle, through the mitral valve, into the left atrium, when the left ventricle contracts. Mitral regurgitation is the most common form of valvular heart disease.

Mitral regurgitation
Other namesMitral incompetence, mitral insufficiency
Mitral regurgitation (schematic drawing)
During systole, contraction of the left ventricle causes abnormal backflow (arrow) into the left atrium.
1 Mitral valve
2 Left ventricle
3 Left atrium
4 Aorta
SpecialtyCardiology
SymptomsHeart murmur, shortness of breath during exercise or lying down, fatigue, palpitations, swollen feet or ankles
ComplicationsIn severe cases: congestive heart failure, arrhythmias (atrial fibrillation), pulmonary hypertension
TypesAcute mitral regurgitation, chronic compensated mitral regurgitation, chronic decompensated mitral regurgitation
Causesmitral valve prolapse, ageing, rheumatic fever, mitral annular calcification, infective endocarditis, hypertrophic cardiomyopathy
TreatmentMedication, Mitral valve repair, Mitral valve replacement, MitraClip
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