Mineralocorticoid receptor

NR3C2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1Y9R, 1YA3, 2A3I, 2AA2, 2AA5, 2AA6, 2AA7, 2AAX, 2AB2, 2ABI, 2OAX, 3VHU, 3VHV, 3WFF, 3WFG, 4PF3, 4TNT, 4UDB, 4UDA, 5HCV
Identifiers
Aliases	NR3C2, MCR, MLR, MR, NR3C2VIT, nuclear receptor subfamily 3 group C member 2
External IDs	OMIM: 600983 MGI: 99459 HomoloGene: 121495 GeneCards: NR3C2
Gene location (Human)
Chr.	Chromosome 4 (human)
End	148,444,698 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	77,971,641 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; rectum; ; middle temporal gyrus; ; Brodmann area 23; ; Achilles tendon; ; jejunal mucosa; ; renal medulla; ; Region I of hippocampus proper; ; parotid gland; ; frontal pole;
	Top expressed in
	Region I of hippocampus proper; ; hippocampus proper; ; left colon; ; dentate gyrus; ; facial motor nucleus; ; ciliary body; ; subiculum; ; olfactory tubercle; ; otolith organ; ; utricle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	sequence-specific DNA binding; DNA binding; DNA-binding transcription factor activity; zinc ion binding; metal ion binding; steroid hormone receptor activity; steroid binding; protein binding; lipid binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	cytoplasm; endoplasmic reticulum membrane; membrane; receptor complex; endoplasmic reticulum; nucleus; nucleoplasm; cytosol;
Biological process	regulation of transcription, DNA-templated; transcription, DNA-templated; transcription initiation from RNA polymerase II promoter; signal transduction; steroid hormone mediated signaling pathway; regulation of transcription by RNA polymerase II; positive regulation of NIK/NF-kappaB signaling;
	Sources:Amigo / QuickGO
Orthologs
	4306
	110784
	ENSG00000151623
	ENSMUSG00000031618
	P08235
	Q8VII8
	NM_000901; NM_001166104; NM_001354819
	NM_001083906
	NP_000892; NP_001159576; NP_001341748
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

The mineralocorticoid receptor (or MR, MLR, MCR), also known as the aldosterone receptor or nuclear receptor subfamily 3, group C, member 2, (NR3C2) is a protein that in humans is encoded by the NR3C2 gene that is located on chromosome 4q31.1-31.2.

MR is a receptor with equal affinity for mineralocorticoids and glucocorticoids. It belongs to the nuclear receptor family where the ligand diffuses into cells, interacts with the receptor and results in a signal transduction affecting specific gene expression in the nucleus. The selective response of some tissues and organs to mineralocorticoids over glucocorticoids occurs because mineralocorticoid-responsive cells express Corticosteroid 11-beta-dehydrogenase isozyme 2, an enzyme which selectively inactivates glucocorticoids more readily than mineralocorticoids.

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