Midodrine

Midodrine
Clinical data
Trade names	Amatine, Proamatine, Gutron, others
Other names	2-amino-N-[2-(2,5-dimethoxyphenyl)-2-hydroxy-ethyl]-acetamide
AHFS/Drugs.com	Monograph
MedlinePlus	a602023
License data	US DailyMed: Midodrine;
Pregnancy; category	AU: C;
Routes of; administration	By mouth
ATC code	C01CA17 (WHO) ;
Legal status
Legal status	AU: S4 (Prescription only); US: ℞-only;
Identifiers
	IUPAC name (RS)- N-[2-(2,5-Dimethoxyphenyl)-2-hydroxyethyl]glycinamide;
CAS Number	42794-76-3 ;
PubChem CID	4195;
IUPHAR/BPS	7240;
DrugBank	DB00211 ;
ChemSpider	4050 ;
UNII	6YE7PBM15H;
KEGG	D08220 ;
ChEBI	CHEBI:6933 ;
ChEMBL	ChEMBL1076 ;
CompTox Dashboard (EPA)	DTXSID0023321 ;
ECHA InfoCard	100.151.349 100.050.842, 100.151.349
Chemical and physical data
Formula	C12H18N2O4
Molar mass	254.286 g·mol−1
3D model (JSmol)	Interactive image;
Chirality	Racemic mixture
	SMILES O=C(NCC(O)c1cc(OC)ccc1OC)CN;
	InChI InChI=1S/C12H18N2O4/c1-17-8-3-4-11(18-2)9(5-8)10(15)7-14-12(16)6-13/h3-5,10,15H,6-7,13H2,1-2H3,(H,14,16) ; Key:PTKSEFOSCHHMPD-UHFFFAOYSA-N ;
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Midodrine is a vasopressor/antihypotensive agent (it raises the blood pressure). Midodrine was approved in the United States by the Food and Drug Administration (FDA) in 1996 for the treatment of dysautonomia and orthostatic hypotension. In August 2010, the FDA proposed withdrawing this approval because the manufacturer, Shire plc, failed to complete required studies after the medicine reached the market. In September 2010, the FDA reversed its decision to remove midodrine from the market and allowed it to remain available to patients while Shire plc collected further data regarding the efficacy and safety of the drug. Shire announced on September 22, 2011, that it was withdrawing completely from supplying midodrine and leaving it to several generics to supply the drug.

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