Methyl-CpG-binding domain protein 2

MBD2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2L2L
Identifiers
Aliases	MBD2, DMTase, NY-CO-41, methyl-CpG binding domain protein 2
External IDs	OMIM: 603547 MGI: 1333813 HomoloGene: 2918 GeneCards: MBD2
Gene location (Human)
Chr.	Chromosome 18 (human)
End	54,224,669 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	70,759,202 bp
RNA expression pattern
	Top expressed in
	thymus; ; cavity of mouth; ; bone marrow cells; ; parotid gland; ; sural nerve; ; monocyte; ; Achilles tendon; ; right lobe of thyroid gland; ; subcutaneous adipose tissue; ; left lobe of thyroid gland;
	Top expressed in
	epithelium of urethra; ; Paneth cell; ; hair follicle; ; aortic valve; ; ascending aorta; ; lip; ; submandibular gland; ; thymus; ; islet of Langerhans; ; blood;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA binding; protein domain specific binding; methyl-CpG binding; C2H2 zinc finger domain binding; chromatin binding; protein binding; siRNA binding; nucleosomal DNA binding; satellite DNA binding; mRNA binding;
Cellular component	cytoplasm; histone deacetylase complex; heterochromatin; chromatin; nucleus; nucleoplasm; cytosol; protein-containing complex;
Biological process	regulation of transcription, DNA-templated; negative regulation of transcription by RNA polymerase II; transcription, DNA-templated; positive regulation of Wnt signaling pathway; regulation of cell population proliferation; maternal behavior; negative regulation of transcription, DNA-templated; human ageing; response to mechanical stimulus; response to estradiol; cellular response to organic cyclic compound; response to nutrient levels; response to organic cyclic compound; positive regulation of chromatin binding; heart development; embryonic organ development; rDNA heterochromatin assembly; regulation of DNA methylation; DNA methylation-dependent heterochromatin assembly;
	Sources:Amigo / QuickGO
Orthologs
	8932
	17191
	ENSG00000134046
	ENSMUSG00000024513
	Q9UBB5
	Q9Z2E1
	NM_015832; NM_003927
	NM_010773; NM_001311071
	NP_003918; NP_056647; NP_056647.1
	NP_001298000; NP_034903
	Wikidata
View/Edit Human	View/Edit Mouse

Methyl-CpG-binding domain protein 2 is a protein that in humans is encoded by the MBD2 gene.

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