Methoxetamine

Methoxetamine
Clinical data
Other names	MXE; 3-MeO-2'-oxo-PCE
Addiction; liability	High
Drug class	NMDA receptor antagonists; Dissociative hallucinogens; General anesthetics
ATC code	None;
Legal status
Legal status	BR: Class F2 (Prohibited psychotropics); CA: Schedule I; DE: Anlage I (Authorized scientific use only); UK: Class B; US: Schedule I (as of July 6, 2022); UN: Psychotropic Schedule II;
Pharmacokinetic data
Elimination half-life	3–6 hours
Identifiers
	IUPAC name (R/S)-2-(3-Methoxyphenyl)-2-(ethylamino)cyclohexanone;
CAS Number	1239943-76-0 ;
PubChem CID	52911279;
ChemSpider	24721792 ;
UNII	ZO5ZCE6E12;
KEGG	C22711;
CompTox Dashboard (EPA)	DTXSID301009327 ;
Chemical and physical data
Formula	C15H21NO2
Molar mass	247.338 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C1CCCCC1(C2=CC=CC(OC)=C2)NCC;
	InChI InChI=1S/C15H21NO2/c1-3-16-15(10-5-4-9-14(15)17)12-7-6-8-13(11-12)18-2/h6-8,11,16H,3-5,9-10H2,1-2H3 ; Key:LPKTWLVEGBNOOX-UHFFFAOYSA-N ;
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Methoxetamine, abbreviated as MXE, is a dissociative hallucinogen that has been sold as a designer drug. It differs from many dissociatives such as ketamine and phencyclidine (PCP) that were developed as pharmaceutical drugs for use as general anesthetics in that it was designed specifically to increase the antidepressant effects of ketamine.

MXE is an arylcyclohexylamine. It acts mainly as an NMDA receptor antagonist, similarly to other arylcyclohexylamines like ketamine and PCP.

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