Metabotropic glutamate receptor 1

GRM1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3KS9, 4OR2
Identifiers
Aliases	GRM1, GPRC1A, MGLU1, MGLUR1, PPP1R85, SCAR13, glutamate metabotropic receptor 1, SCA44
External IDs	OMIM: 604473 MGI: 1351338 HomoloGene: 649 GeneCards: GRM1
Gene location (Human)
Chr.	Chromosome 6 (human)
End	146,437,601 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	10,958,100 bp
RNA expression pattern
	Top expressed in
	cerebellar vermis; ; middle temporal gyrus; ; endothelial cell; ; Brodmann area 23; ; cerebellar hemisphere; ; pons; ; optic nerve; ; superior frontal gyrus; ; Brodmann area 46; ; postcentral gyrus;
	Top expressed in
	medial dorsal nucleus; ; medial geniculate nucleus; ; lateral geniculate nucleus; ; cerebellar vermis; ; mammillary body; ; superior colliculus; ; globus pallidus; ; lateral hypothalamus; ; olfactory tubercle; ; dorsomedial hypothalamic nucleus;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	glutamate receptor activity; G protein-coupled receptor activity; signal transducer activity; protein binding; neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration; identical protein binding; G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration; G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential;
Cellular component	integral component of membrane; G protein-coupled receptor dimeric complex; postsynaptic density; membrane; G protein-coupled receptor homodimeric complex; plasma membrane; integral component of plasma membrane; dendrite; neuron projection; nucleus; presynaptic membrane; Schaffer collateral - CA1 synapse; glutamatergic synapse; postsynaptic density membrane;
Biological process	cellular response to electrical stimulus; G protein-coupled glutamate receptor signaling pathway; positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway; regulation of MAPK cascade; regulation of sensory perception of pain; locomotory behavior; sensory perception of pain; signal transduction; chemical synaptic transmission; regulation of synaptic transmission, glutamatergic; adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway; regulation of postsynaptic cytosolic calcium ion concentration; G protein-coupled receptor signaling pathway; regulation of postsynaptic membrane potential;
	Sources:Amigo / QuickGO
Orthologs
	2911
	14816
	ENSG00000152822
	ENSMUSG00000019828
	Q13255
	P97772
NM_000838; NM_001114329; NM_001278064; NM_001278065; NM_001278066;
	NM_001278067
	NM_001114333; NM_016976
	NP_001264993; NP_001264994; NP_001264995; NP_001264996
	NP_001107805; NP_058672
	Wikidata
View/Edit Human	View/Edit Mouse

The glutamate receptor, metabotropic 1, also known as GRM1, is a human gene which encodes the metabotropic glutamate receptor 1 (mGluR1) protein.

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