Merozoite surface protein

Merozoite /ˌmɛrəˈzˌt/ surface proteins are both integral and peripheral membrane proteins found on the surface of a merozoite, an early life cycle stage of a protozoan. Merozoite surface proteins, or MSPs, are important in understanding malaria, a disease caused by protozoans of the genus Plasmodium. During the asexual blood stage of its life cycle, the malaria parasite enters red blood cells to replicate itself, causing the classic symptoms of malaria. These surface protein complexes are involved in many interactions of the parasite with red blood cells and are therefore an important topic of study for scientists aiming to combat malaria.

Merozoite Surface Protein-1
The MSP-1 complex is attached to the merozoite cell membrane via GPI-anchoring, indicated by the staggered lines penetrating the cell membrane. After red blood cell invasion, the majority of the MSP-1 complex is shed, leaving MSP-119 behind.
Identifiers
OrganismPlasmodium knowlesi
SymbolMSP1
Alt. symbolsPKH_072850
Entrez7320035
PDB1N1I
RefSeq (mRNA)XM_002258546.1
RefSeq (Prot)XP_002258582.1
UniProtQ9GSQ9
Other data
Chromosome7: 1.26 - 1.27 Mb
Search for
StructuresSwiss-model
DomainsInterPro
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