Meropenem/vaborbactam

Meropenem/vaborbactam, sold under the brand name Vabomere among others, is a combination medication used to treat complicated urinary tract infections, complicated abdominal infections, and hospital-acquired pneumonia. It contains meropenem, a β-lactam antibiotic, and vaborbactam, a β-lactamase inhibitor. It is given by injection into a vein.

Meropenem/vaborbactam
Combination of
Meropenemβ-lactam antibiotic
Vaborbactamβ-lactamase inhibitor
Clinical data
Trade namesVabomere, Vaborem, others
AHFS/Drugs.comMonograph
License data
Routes of
administration		Intravenous
ATC code
Legal status
Legal status
Identifiers
CAS Number
KEGG

Common side effects include headache, inflammation at the site of injection, nausea, diarrhea, liver inflammation, and low blood potassium. Severe side effects may include anaphylaxis, seizures, and Clostridium difficile-associated diarrhea. It is unclear if use during pregnancy is safe. Meropenem works by blocking the construction of the bacterial cell wall while vaborbactam blocks the breakdown of meropenem by some β-lactamases.

The combination was approved for medical use in the United States in 2017 and Europe in 2018. It is on the World Health Organization's List of Essential Medicines.

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