Mephentermine

Mephentermine (Wyamine, former brandname) is a cardiac stimulant.

Mephentermine
Clinical data
Other namesmethyl(2-methyl-1-phenylpropan-2-yl)amine
Routes of
administration
IM/IV
ATC code
Legal status
Legal status
Pharmacokinetic data
MetabolismRapidly demethylated in the body followed by hydroxylation.
ExcretionVia urine (as unchanged and metabolites); more rapid in acidic urine.
Identifiers
  • N,2-dimethyl-1-phenylpropan-2-amine
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.002.638
Chemical and physical data
FormulaC11H17N
Molar mass163.264 g·mol−1
3D model (JSmol)
  • N(C(Cc1ccccc1)(C)C)C
  • InChI=1S/C11H17N/c1-11(2,12-3)9-10-7-5-4-6-8-10/h4-8,12H,9H2,1-3H3 Y
  • Key:RXQCGGRTAILOIN-UHFFFAOYSA-N Y
 NY (what is this?)  (verify)

It has been used as a treatment for low blood pressure.

Mephentermine belongs to the class of adrenergic and dopaminergic cardiac stimulants excluding cardiac glycosides. Used in the treatment of heart failure.

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