Masitinib

Masitinib
Clinical data
Trade names	Masivet, Kinavet
AHFS/Drugs.com	International Drug Names
ATC code	L01EX06 (WHO) ;
Identifiers
	IUPAC name 4-[(4-Methylpiperazin-1-yl)methyl]-N-(4-methyl-3-{[4-(pyridin-3-yl)-1,3-thiazol-2-yl]amino}phenyl)benzamide;
CAS Number	790299-79-5;
PubChem CID	10074640;
ChemSpider	8250179;
UNII	M59NC4E26P;
KEGG	D10229;
ChEMBL	ChEMBL1908391;
PDB ligand	G65 (PDBe, RCSB PDB);
CompTox Dashboard (EPA)	DTXSID001000207 ;
Chemical and physical data
Formula	C28H30N6OS
Molar mass	498.65 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(c1ccc(cc1)CN2CCN(C)CC2)Nc3cc(c(cc3)C)Nc4nc(cs4)c5cccnc5;
	InChI InChI=InChI=1S/C28H30N6OSc1-20-5-10-24(16-25(20)31-28-32-26(19-36-28)23-4-3-11-29-17-23)30-27(35)22-8-6-21(7-9-22)18-34-14-12-33(2)13-15-34h3-11,16-17,19H,12-15,18H2,1-2H3,(H,30,35)(H,31,32); Key:WJEOLQLKVOPQFV-UHFFFAOYSA-N;

Masitinib is a tyrosine-kinase inhibitor used in the treatment of mast cell tumours in animals, specifically dogs. Since its introduction in November 2008 it has been distributed under the commercial name Masivet. It has been available in Europe since the second part of 2009. Masitinib has been studied for several human conditions including melanoma, multiple myeloma, gastrointestinal cancer, pancreatic cancer, Alzheimer disease, multiple sclerosis, rheumatoid arthritis, mastocytosis, amyotrophic lateral sclerosis and COVID-19.

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