Mannan-binding lectin

MBL2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1HUP
Identifiers
Aliases	MBL2, COLEC1, HSMBPC, MBL, MBL2D, MBP, MBP-C, MBP1, MBPD, mannose binding lectin 2
External IDs	OMIM: 154545 MGI: 96924 HomoloGene: 110436 GeneCards: MBL2
Gene location (Human)
Chr.	Chromosome 10 (human)
End	52,772,784 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	30,217,087 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; kidney; ; haematopoietic system; ; atrium; ; right atrium; ; spleen; ; stomach; ; intestine; ; skin of abdomen; ; male reproductive system;
	Top expressed in
	left lobe of liver; ; secondary oocyte; ; yolk sac; ; gallbladder; ; plantaris muscle; ; extensor digitorum longus muscle; ; morula; ; jejunum; ; sexually immature organism; ; olfactory epithelium;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; calcium-dependent protein binding; protein binding; mannose binding; signaling receptor binding; carbohydrate binding; serine-type endopeptidase activity;
Cellular component	collagen; extracellular region; cell surface; extracellular space; extracellular matrix; collagen-containing extracellular matrix;
Biological process	complement activation, lectin pathway; positive regulation of phagocytosis; killing by host of symbiont cells; negative regulation of viral process; immune system process; complement activation; response to oxidative stress; acute-phase response; defense response to bacterium; complement activation, classical pathway; opsonization; defense response to Gram-positive bacterium; innate immune response; proteolysis; growth plate cartilage chondrocyte morphogenesis;
	Sources:Amigo / QuickGO
Orthologs
	4153
	17195
	ENSG00000165471
	ENSMUSG00000024863
	P11226
	P41317
	NM_000242; NM_001378373; NM_001378374
	NM_010776; NM_001365058
	NP_000233; NP_001365302; NP_001365303
	NP_034906; NP_001351987
	Wikidata
View/Edit Human	View/Edit Mouse

Mannose-binding lectin (MBL), also called mannan-binding lectin or mannan-binding protein (MBP), is a lectin that is instrumental in innate immunity as an opsonin and via the lectin pathway.

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