Myocilin

MYOC
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4WXQ, 4WXS, 4WXU
Identifiers
Aliases	MYOC, GLC1A, GPOA, JOAG, JOAG1, TIGR, myocilin
External IDs	OMIM: 601652 MGI: 1202864 HomoloGene: 220 GeneCards: MYOC
Gene location (Human)
Chr.	Chromosome 1 (human)
End	171,652,688 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	162,477,262 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; gastric mucosa; ; synovial joint; ; tibial nerve; ; popliteal artery; ; right coronary artery; ; trachea; ; fundus; ; triceps brachii muscle; ; left coronary artery;
	Top expressed in
	ankle; ; lip; ; extensor digitorum longus muscle; ; intercostal muscle; ; plantaris muscle; ; gastrocnemius muscle; ; quadriceps femoris muscle; ; sciatic nerve; ; masseter muscle; ; temporal muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	frizzled binding; receptor tyrosine kinase binding; myosin light chain binding; protein binding; fibronectin binding; metal ion binding;
Cellular component	mitochondrial outer membrane; cytoplasmic vesicle; rough endoplasmic reticulum; node of Ranvier; mitochondrial intermembrane space; cell projection; extracellular exosome; membrane; endoplasmic reticulum; extracellular matrix; Golgi apparatus; extracellular region; mitochondrion; cilium; mitochondrial inner membrane; extracellular space; collagen-containing extracellular matrix;
Biological process	non-canonical Wnt signaling pathway via JNK cascade; regulation of cell-matrix adhesion; positive regulation of substrate adhesion-dependent cell spreading; myelination in peripheral nervous system; negative regulation of stress fiber assembly; positive regulation of focal adhesion assembly; positive regulation of phosphatidylinositol 3-kinase signaling; positive regulation of mitochondrial depolarization; ERBB2-ERBB3 signaling pathway; positive regulation of stress fiber assembly; clustering of voltage-gated sodium channels; bone development; positive regulation of cell migration; regulation of stress fiber assembly; negative regulation of Rho protein signal transduction; osteoblast differentiation; positive regulation of protein kinase B signaling; skeletal muscle hypertrophy; neuron projection development; regulation of MAPK cascade; negative regulation of cell-matrix adhesion;
	Sources:Amigo / QuickGO
Orthologs
	4653
	17926
	ENSG00000034971
	ENSMUSG00000026697
	Q99972
	O70624
	NM_000261
	NM_010865
	NP_000252
	NP_034995
	Wikidata
View/Edit Human	View/Edit Mouse

Myocilin, trabecular meshwork inducible glucocorticoid response (TIGR), also known as MYOC, is a protein which in humans is encoded by the MYOC gene. Mutations in MYOC are a major cause of glaucoma.

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