MX2

MX2
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	4WHJ, 4X0R
Identifiers
Aliases	MX2, MXB, MX dynamin like GTPase 2
External IDs	OMIM: 147890 HomoloGene: 74299 GeneCards: MX2
Gene location (Human)
Chr.	Chromosome 21 (human)
End	41,409,393 bp
RNA expression pattern
	Top expressed in
	blood; ; monocyte; ; pancreatic ductal cell; ; spleen; ; gallbladder; ; bone marrow cells; ; appendix; ; periodontal fiber; ; lymph node; ; subcutaneous adipose tissue;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; GTP binding; protein binding; microtubule binding; GTPase activity;
Cellular component	cytosol; cytoplasm; nuclear pore; nucleus; mitochondrial membranes; membrane;
Biological process	defense response; regulation of nucleocytoplasmic transport; mRNA transport; immune system process; response to virus; regulation of cell cycle; defense response to virus; type I interferon signaling pathway; response to interferon-alpha; protein transport; innate immune response; mitochondrial fission; dynamin family protein polymerization involved in mitochondrial fission; membrane fusion;
	Sources:Amigo / QuickGO
Orthologs
	4600
	n/a
	ENSG00000183486
	n/a
	P20592
	n/a
	NM_002463
	n/a
	NP_002454
	n/a
	Wikidata
View/Edit Human

Interferon-induced GTP-binding protein Mx2 is a protein that in humans is encoded by the MX2 gene.

The protein encoded by this gene has a nuclear and a cytoplasmic form and is a member of both the dynamin family and the family of large GTPases. The nuclear form is localized in a granular pattern in the heterochromatin region beneath the nuclear envelope. A nuclear localization signal (NLS) is present at the amino terminal end of the nuclear form but is lacking in the cytoplasmic form due to use of an alternate translation start codon.

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