MMP8

MMP8
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1A86, 1JAP, 1I76, 1ZVX, 3TT4, 2OY2, 1ZS0, 1JAN, 1MMB, 1I73, 1A85, 1KBC, 1ZP5, 1JH1, 3DPF, 1JAQ, 3DPE, 1BZS, 4QKZ, 1JAO, 3DNG, 2OY4, 1MNC
Identifiers
Aliases	MMP8, CLG1, HNC, MMP-8, PMNL-CL, matrix metallopeptidase 8
External IDs	OMIM: 120355 MGI: 1202395 HomoloGene: 22482 GeneCards: MMP8
Gene location (Human)
Chr.	Chromosome 11 (human)
End	102,727,050 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	7,568,486 bp
RNA expression pattern
	Top expressed in
	spongy bone; ; bone marrow; ; bone marrow cells; ; monocyte; ; blood; ; amniotic fluid; ; spleen; ; upper lobe of left lung; ; right lung; ; lower lobe of lung;
	Top expressed in
	third toe; ; bone marrow; ; blood; ; second toe; ; hallux; ; axial skeleton; ; clavicle; ; femur; ; body of femur; ; spleen;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	zinc ion binding; peptidase activity; hydrolase activity; metallopeptidase activity; metal ion binding; serine-type endopeptidase activity; metalloendopeptidase activity; endopeptidase activity;
Cellular component	extracellular matrix; extracellular region; specific granule lumen; tertiary granule lumen; extracellular space; collagen-containing extracellular matrix;
Biological process	collagen catabolic process; extracellular matrix disassembly; endodermal cell differentiation; proteolysis; neutrophil degranulation; positive regulation of gene expression; negative regulation of gene expression; negative regulation of interleukin-10 production; positive regulation of interleukin-6 production; positive regulation of DNA binding; positive regulation of MAPK cascade; positive regulation of nitric oxide biosynthetic process; positive regulation of JNK cascade; regulation of neuroinflammatory response; positive regulation of neuroinflammatory response; positive regulation of NIK/NF-kappaB signaling; positive regulation of reactive oxygen species biosynthetic process; regulation of microglial cell activation; positive regulation of microglial cell activation; extracellular matrix organization;
	Sources:Amigo / QuickGO
Orthologs
	4317
	17394
	ENSG00000118113
	ENSMUSG00000005800
	P22894
	O70138
	NM_001304441; NM_001304442; NM_002424
	NM_008611
	NP_001291370; NP_001291371; NP_002415
	NP_032637
	Wikidata
View/Edit Human	View/Edit Mouse

Neutrophil collagenase, also known as matrix metalloproteinase-8 (MMP-8) or PMNL collagenase (MNL-CL), is a collagen cleaving enzyme which is present in the connective tissue of most mammals. In humans, the MMP-8 protein is encoded by the MMP8 gene. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is stored in secondary granules within neutrophils and is activated by autolytic cleavage.

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