MAP2K6

MAP2K6
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2Y8O, 3ENM, 3FME, 3VN9
Identifiers
Aliases	MAP2K6, MAPKK6, MEK6, MKK6, PRKMK6, SAPKK-3, SAPKK3, mitogen-activated protein kinase kinase 6
External IDs	OMIM: 601254 MGI: 1346870 HomoloGene: 55686 GeneCards: MAP2K6
Gene location (Human)
Chr.	Chromosome 17 (human)
End	69,553,865 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	110,525,522 bp
RNA expression pattern
	Top expressed in
	rectum; ; biceps brachii; ; vastus lateralis muscle; ; gastrocnemius muscle; ; triceps brachii muscle; ; deltoid muscle; ; Achilles tendon; ; body of tongue; ; monocyte; ; endometrium;
	Top expressed in
	triceps brachii muscle; ; temporal muscle; ; sternocleidomastoid muscle; ; maxillary prominence; ; somite; ; vastus lateralis muscle; ; gastrocnemius muscle; ; hand; ; tibialis anterior muscle; ; soleus muscle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; kinase activity; protein binding; protein tyrosine kinase activity; ATP binding; protein kinase binding; protein serine/threonine kinase activity; identical protein binding; MAP kinase kinase activity;
Cellular component	cytoplasm; nucleoplasm; cytoskeleton; nucleus; cytosol;
Biological process	positive regulation of protein phosphorylation; regulation of transcription, DNA-templated; cardiac muscle contraction; phosphorylation; cellular response to sorbitol; positive regulation of nitric-oxide synthase biosynthetic process; ovulation cycle process; transcription, DNA-templated; MAPK cascade; protein phosphorylation; positive regulation of prostaglandin secretion; response to ischemia; DNA damage induced protein phosphorylation; positive regulation of apoptotic process; peptidyl-tyrosine phosphorylation; nucleotide-binding oligomerization domain containing signaling pathway; signal transduction; apoptotic process; regulation of mitotic cell cycle; stress-activated protein kinase signaling cascade; activation of protein kinase activity; regulation of apoptotic process; negative regulation of cold-induced thermogenesis;
	Sources:Amigo / QuickGO
Orthologs
	5608
	26399
	ENSG00000108984
	ENSMUSG00000020623
	P52564
	P70236
	NM_002758; NM_031988; NM_001330450
	NM_011943
	NP_001317379; NP_002749
NP_036073; NP_001343274; NP_001343275; NP_001343276; NP_001343281;
	NP_001343282
	Wikidata
View/Edit Human	View/Edit Mouse

Dual specificity mitogen-activated protein kinase kinase 6 also known as MAP kinase kinase 6 (MAPKK 6) or MAPK/ERK kinase 6 is an enzyme that in humans is encoded by the MAP2K6 gene, on chromosome 17.

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