MAP2K5

MAP2K5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2NPT, 2O2V, 4IC7
Identifiers
Aliases	MAP2K5, HsT17454, MAPKK5, MEK5, PRKMK5, mitogen-activated protein kinase kinase 5
External IDs	OMIM: 602520 MGI: 1346345 HomoloGene: 115933 GeneCards: MAP2K5
Gene location (Human)
Chr.	Chromosome 15 (human)
End	67,807,117 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	63,285,184 bp
RNA expression pattern
	Top expressed in
	parotid gland; ; Achilles tendon; ; gastrocnemius muscle; ; Brodmann area 9; ; prefrontal cortex; ; sural nerve; ; sperm; ; cingulate gyrus; ; middle temporal gyrus; ; right adrenal gland;
	Top expressed in
	internal carotid artery; ; external carotid artery; ; motor neuron; ; spermatocyte; ; seminiferous tubule; ; primitive streak; ; left lobe of liver; ; proximal tubule; ; condyle; ; fossa;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; protein kinase activity; nucleotide binding; metal ion binding; kinase activity; protein binding; protein tyrosine kinase activity; ATP binding; protein serine/threonine kinase activity; MAP kinase kinase activity;
Cellular component	cytoplasm; cytosol; spindle; nucleus; intracellular anatomical structure;
Biological process	negative regulation of chemokine (C-X-C motif) ligand 2 production; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; phosphorylation; positive regulation of epithelial cell proliferation; cellular response to laminar fluid shear stress; cellular response to growth factor stimulus; negative regulation of transcription by RNA polymerase II; negative regulation of response to cytokine stimulus; MAPK cascade; ERK5 cascade; negative regulation of cell migration involved in sprouting angiogenesis; protein phosphorylation; heart development; positive regulation of cell growth; peptidyl-tyrosine phosphorylation; negative regulation of heterotypic cell-cell adhesion; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; negative regulation of NF-kappaB transcription factor activity; signal transduction; positive regulation of transcription by RNA polymerase II; regulation of mitotic cell cycle; stress-activated protein kinase signaling cascade; activation of protein kinase activity; regulation of apoptotic process;
	Sources:Amigo / QuickGO
Orthologs
	5607
	23938
	ENSG00000137764
	ENSMUSG00000058444
	Q13163
	Q9WVS7
	NM_001206804; NM_002757; NM_145160; NM_145161; NM_145162
	NM_011840; NM_001364492; NM_001364493; NM_001364494
	NP_001193733; NP_002748; NP_660143
	NP_035970; NP_001351421; NP_001351422; NP_001351423
	Wikidata
View/Edit Human	View/Edit Mouse

Dual specificity mitogen-activated protein kinase kinase 5 is an enzyme that in humans is encoded by the MAP2K5 gene.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.