METTL3

METTL3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	5IL0, 5IL2, 5IL1, 5K7M, 5K7U, 5K7W
Identifiers
Aliases	METTL3, IME4, M6A, MT-A70, Spo8, methyltransferase like 3, hmethyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit
External IDs	OMIM: 612472 MGI: 1927165 HomoloGene: 10501 GeneCards: METTL3
Gene location (Human)
Chr.	Chromosome 14 (human)
End	21,511,342 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	52,542,585 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; left lobe of thyroid gland; ; right lobe of thyroid gland; ; body of pancreas; ; tibial nerve; ; canal of the cervix; ; endothelial cell; ; middle temporal gyrus; ; left uterine tube; ; lymph node;
	Top expressed in
	saccule; ; Paneth cell; ; primitive streak; ; otic placode; ; facial motor nucleus; ; secondary oocyte; ; thymus; ; urothelium; ; retinal pigment epithelium; ; substantia nigra;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	methyltransferase activity; transferase activity; RNA binding; RNA methyltransferase activity; mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity; mRNA binding; S-adenosyl-L-methionine binding; protein heterodimerization activity; protein binding; mRNA (N6-adenosine)-methyltransferase activity;
Cellular component	RNA N6-methyladenosine methyltransferase complex; nucleoplasm; nuclear speck; nucleus; cytoplasm;
Biological process	rhythmic process; mRNA processing; positive regulation of cap-independent translational initiation; stem cell population maintenance; methylation; mRNA methylation; mRNA destabilization; circadian rhythm; primary miRNA processing; adenosine to inosine editing; RNA methylation; mRNA splicing, via spliceosome; mRNA catabolic process; forebrain radial glial cell differentiation; cellular response to UV; gliogenesis; regulation of T cell differentiation; negative regulation of Notch signaling pathway; regulation of meiotic cell cycle; endothelial to hematopoietic transition; regulation of hematopoietic stem cell differentiation; cellular response to DNA damage stimulus; spermatogenesis; cell differentiation; dosage compensation by inactivation of X chromosome; RNA metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	56339
	56335
	ENSG00000165819
	ENSMUSG00000022160
	Q86U44
	Q8C3P7
	NM_019852
	NM_019721
	NP_062826
	NP_062695
	Wikidata
View/Edit Human	View/Edit Mouse

N6-adenosine-methyltransferase 70 kDa subunit (METTL3) is an enzyme that in humans is encoded by the METTL3 gene.

This gene encodes the 70 kDa subunit of MT-A which is part of N6-adenosine-methyltransferase. This enzyme is involved in the post-transcriptional methylation of internal adenosine residues in eukaryotic mRNAs, forming N6-methyladenosine (m⁶A).

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