MAP2K2

MAP2K2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1S9I, 4H3Q
Identifiers
Aliases	MAP2K2, CFC4, MAPKK2, MEK2, MKK2, PRKMK2, mitogen-activated protein kinase kinase 2
External IDs	OMIM: 601263 MGI: 1346867 HomoloGene: 48591 GeneCards: MAP2K2
Gene location (Human)
Chr.	Chromosome 19 (human)
End	4,124,122 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	80,969,809 bp
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; anterior pituitary; ; prefrontal cortex; ; stromal cell of endometrium; ; amygdala; ; right adrenal gland; ; cingulate gyrus; ; ganglionic eminence; ; right lobe of thyroid gland; ; body of pancreas;
	Top expressed in
	lip; ; yolk sac; ; neural tube; ; duodenum; ; esophagus; ; superior frontal gyrus; ; epithelium of stomach; ; jejunum; ; ileum; ; lacrimal gland;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; PDZ domain binding; scaffold protein binding; protein serine/threonine kinase activator activity; metal ion binding; kinase activity; protein binding; protein serine/threonine/tyrosine kinase activity; protein tyrosine kinase activity; ATP binding; MAP kinase kinase activity; protein serine/threonine kinase activity;
Cellular component	late endosome; Golgi apparatus; membrane; focal adhesion; cell-cell junction; peroxisomal membrane; extracellular region; early endosome; endoplasmic reticulum; mitochondrion; perinuclear region of cytoplasm; cytoplasmic side of plasma membrane; microtubule; nucleus; cytoplasm; cytosol; plasma membrane;
Biological process	phosphorylation; regulation of early endosome to late endosome transport; peptidyl-serine autophosphorylation; negative regulation of gene expression; positive regulation of protein serine/threonine kinase activity; protein phosphorylation; peptidyl-tyrosine phosphorylation; regulation of Golgi inheritance; regulation of stress-activated MAPK cascade; MAPK cascade; ERK1 and ERK2 cascade; positive regulation of production of miRNAs involved in gene silencing by miRNA; positive regulation of transcription, DNA-templated; positive regulation of ERK1 and ERK2 cascade; regulation of mitotic cell cycle; regulation of apoptotic process; signal transduction; stress-activated protein kinase signaling cascade; activation of protein kinase activity;
	Sources:Amigo / QuickGO
Orthologs
	5605
	26396
	ENSG00000126934
	ENSMUSG00000035027
	P36507
	Q63932
	NM_030662
	NM_023138; NM_001347144; NM_001358539
	NP_109587
	NP_001334073; NP_075627; NP_001345468
	Wikidata
View/Edit Human	View/Edit Mouse

Dual specificity mitogen-activated protein kinase kinase 2 is an enzyme that in humans is encoded by the MAP2K2 gene. It is more commonly known as MEK2, but has many alternative names including CFC4, MKK2, MAPKK2 and PRKMK2.

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