MAGOH

MAGOH
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1P27, 2HYI, 2J0Q, 2J0S, 2XB2, 3EX7
Identifiers
Aliases	MAGOH, MAGOH1, MAGOHA, mago homolog, exon junction complex core component, mago homolog, exon junction complex subunit
External IDs	OMIM: 602603 MGI: 1330312 HomoloGene: 1776 GeneCards: MAGOH
Gene location (Human)
Chr.	Chromosome 1 (human)
End	53,238,518 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	107,744,621 bp
RNA expression pattern
	Top expressed in
	oocyte; ; secondary oocyte; ; monocyte; ; rectum; ; left lobe of thyroid gland; ; islet of Langerhans; ; right lobe of thyroid gland; ; anterior pituitary; ; left uterine tube; ; left coronary artery;
	Top expressed in
	secondary oocyte; ; yolk sac; ; placenta; ; morula; ; thymus; ; lens; ; ganglionic eminence; ; neural tube; ; lung; ; stomach;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; RNA binding;
Cellular component	cytoplasm; nuclear speck; catalytic step 2 spliceosome; exon-exon junction complex; nucleoplasm; spliceosomal complex; nucleus;
Biological process	mRNA splicing, via spliceosome; termination of RNA polymerase II transcription; mRNA transport; mRNA processing; regulation of alternative mRNA splicing, via spliceosome; mRNA export from nucleus; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; mRNA 3'-end processing; regulation of translation; RNA splicing; RNA export from nucleus; transport;
	Sources:Amigo / QuickGO
Orthologs
	4116
	17149
	ENSG00000162385
	ENSMUSG00000028609
	P61326
	P61327
	NM_002370
	NM_001282737
	NP_002361
	NP_001269666
	Wikidata
View/Edit Human	View/Edit Mouse

Protein mago nashi homolog is a protein that in humans is encoded by the MAGOH gene.

Drosophila that have mutations in their mago nashi (grandchildless) gene produce progeny with defects in germplasm assembly and germline development. This gene encodes the mammalian mago nashi homolog. In mammals, mRNA expression is not limited to the germ plasm, but is expressed ubiquitously in adult tissues and can be induced by serum stimulation of quiescent fibroblasts.

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