Lymphoid enhancer-binding factor 1

LEF1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2LEF, 3OUW, 3OUX
Identifiers
Aliases	LEF1, LEF-1, TCF10, TCF1ALPHA, TCF7L3, lymphoid enhancer binding factor 1
External IDs	MGI: 96770 HomoloGene: 7813 GeneCards: LEF1
Gene location (Human)
Chr.	Chromosome 4 (human)
End	108,168,956 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	131,018,005 bp
RNA expression pattern
	Top expressed in
	thymus; ; lymph node; ; tibia; ; oocyte; ; secondary oocyte; ; blood; ; appendix; ; endometrium; ; caput epididymis; ; sperm;
	Top expressed in
	thymus; ; maxillary prominence; ; blood; ; hair follicle; ; dental papilla; ; secondary oocyte; ; primitive streak; ; endocardial cushion; ; spermatocyte; ; lateral geniculate nucleus;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	DNA-binding transcription factor activity; DNA-binding transcription activator activity, RNA polymerase II-specific; histone deacetylase binding; armadillo repeat domain binding; estrogen receptor binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; transcription factor binding; estrogen receptor activity; gamma-catenin binding; histone binding; C2H2 zinc finger domain binding; chromatin binding; cysteine-type endopeptidase inhibitor activity involved in apoptotic process; protein binding; DNA binding, bending; DNA binding; sequence-specific DNA binding; transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; beta-catenin binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	cytoplasm; nucleus; transcription regulator complex; beta-catenin-TCF complex; nucleoplasm; protein-DNA complex;
Biological process	somitogenesis; tongue development; paraxial mesoderm formation; regulation of transcription by RNA polymerase II; negative regulation of DNA binding; T cell receptor V(D)J recombination; transcription by RNA polymerase II; cellular response to cytokine stimulus; mammary gland development; negative regulation of interleukin-13 production; odontogenesis of dentin-containing tooth; apoptotic process involved in blood vessel morphogenesis; cell chemotaxis; negative regulation of canonical Wnt signaling pathway; face morphogenesis; neutrophil differentiation; negative regulation of interleukin-5 production; regulation of transcription, DNA-templated; dentate gyrus development; apoptotic process involved in morphogenesis; transcription, DNA-templated; positive regulation of transcription, DNA-templated; positive regulation of cell growth; regulation of Wnt signaling pathway; embryonic limb morphogenesis; hypothalamus development; branching involved in blood vessel morphogenesis; trachea gland development; regulation of striated muscle tissue development; positive regulation of cell-cell adhesion; forebrain neuroblast division; eye pigmentation; negative regulation of apoptotic process; sprouting angiogenesis; negative regulation of transcription by RNA polymerase II; positive regulation of epithelial to mesenchymal transition; BMP signaling pathway; positive regulation of cell cycle process; osteoblast differentiation; histone H3 acetylation; formation of radial glial scaffolds; positive regulation of granulocyte differentiation; alpha-beta T cell differentiation; canonical Wnt signaling pathway; negative regulation of transcription, DNA-templated; sensory perception of taste; cellular response to interleukin-4; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; cell development; negative regulation of cell-cell adhesion; negative regulation of interleukin-4 production; negative regulation of striated muscle tissue development; positive regulation of cell migration; Wnt signaling pathway; T-helper 1 cell differentiation; positive regulation of cell proliferation in bone marrow; anatomical structure regression; chorio-allantoic fusion; negative regulation of apoptotic process in bone marrow cell; B cell proliferation; positive regulation of gene expression; vasculature development; forebrain radial glial cell differentiation; neural crest cell migration; positive regulation of cell population proliferation; forebrain neuron differentiation; histone H4 acetylation; hippocampus development; positive regulation of transcription by RNA polymerase II; Wnt signaling pathway, calcium modulating pathway; steroid hormone mediated signaling pathway; odontoblast differentiation; beta-catenin-TCF complex assembly; epithelial to mesenchymal transition; regulation of cell-cell adhesion; secondary palate development;
	Sources:Amigo / QuickGO
Orthologs
	51176
	16842
	ENSG00000138795
	ENSMUSG00000027985
	Q9UJU2; Q659G9
	P27782
	NM_001130713; NM_001130714; NM_001166119; NM_016269
NM_001276402; NM_001276403; NM_010703; NM_001379059; NM_001379060;
	NM_001379061; NM_001379062
	NP_001124185; NP_001124186; NP_001159591; NP_057353; NP_057353.1
NP_001263331; NP_001263332; NP_034833; NP_001365988; NP_001365989;
	NP_001365990; NP_001365991
	Wikidata
View/Edit Human	View/Edit Mouse

Lymphoid enhancer-binding factor 1 (LEF1) is a protein that in humans is encoded by the LEF1 gene. It is a member of T cell factor/lymphoid enhancer factor (TCF/LEF) family.

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